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Ganglion cell complex in early and intermediate age-related macular degeneration: evidence by SD-OCT manual segmentation

dc.contributor.authorCamacho, Pedro
dc.contributor.authorDutra-Medeiros, Marco
dc.contributor.authorPáris, Liliana
dc.date.accessioned2017-08-21T15:42:54Z
dc.date.available2017-08-21T15:42:54Z
dc.date.issued2017-08
dc.description.abstractPurpose: To evaluate ganglion cell layer (GCL) and ganglion cell complex (GCC) thickness manually by spectral-domain optical coherence tomography in subjects with early and intermediate age-related macular degeneration (AMD) in 12 locations on the horizontal meridian. Methods: A total of 450 eyes (specifically, 246 eyes classified as having early/intermediate AMD plus 204 control eyes) were studied. Mann-Whitney U and Kruskal-Wallis tests were used to compare values between the healthy controls and the AMD group and also between the subgroups under study. Diagnostic performance was also compared calculating the areas under the receiver operating characteristic curve. Results: The manual layer segmentation showed clear boundaries between the GCL and the GCC. It was in the temporal GCC that more changes were found. Conclusions: The GCC, especially in the temporal region, allowed the discrimination of differences between various subgroups that have faint variations as well as between early AMD and the first signs of aging.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCamacho P, Dutra-Medeiros M, Páris L. Ganglion cell complex in early and intermediate age-related macular degeneration: evidence by SD-OCT manual segmentation. Ophthalmologica. 2017;238(1-2):31-43.pt_PT
dc.identifier.doi10.1159/000468965pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7340
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKarger Publisherspt_PT
dc.relation.publisherversionhttps://www.karger.com/Article/Abstract/468965pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOphthalmologypt_PT
dc.subjectGanglion cell layerpt_PT
dc.subjectGanglion cell complexpt_PT
dc.subjectAge-related macular degenerationpt_PT
dc.subjectMacular degenerationpt_PT
dc.subjectSpectral-domain optical coherence tomographypt_PT
dc.titleGanglion cell complex in early and intermediate age-related macular degeneration: evidence by SD-OCT manual segmentationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage43pt_PT
oaire.citation.issue1-2pt_PT
oaire.citation.startPage31pt_PT
oaire.citation.titleOphthalmologicapt_PT
oaire.citation.volume238pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

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