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Green tea epigallocatechin-3-gallate (EGCG) oxidative stress and DNA damage

2019-06Conference object Open access
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dc.contributor.authorLadeira, Carina
dc.contributor.authorPádua, Mário
dc.contributor.authorRamos, Carina
dc.contributor.authorRibeiro, Edna
dc.date.accessioned2022-03-04T12:44:13Z
dc.date.available2022-03-04T12:44:13Z
dc.date.issued2019-06
dc.description.abstractEpigallocatechin-3-gallate (EGCG) antioxidant properties have been demonstrated however, increasing evidence indicates that EGCG produces reactive oxygen species. The aim of this study was to evaluate the effect of EGCG intake during 90 days in hematological cardiovascular risk factors, vitamins A and E, DNA damage, and oxidative damage in human blood. Peripheral blood from 30 healthy individuals (10 males and 20 females; 18 – 45 years), was collected at time 0 (T0) and time 90 (T90). During 90 days, participants ingested capsules of green tea extract (225mg EGCG) daily. Hematological cardiovascular risk factors including lipid profile and liver function parameters were assessed using colorimetric methods. Vitamins A and E in serum were quantified by HPLC and analysis of DNA damage and oxidative damage was performed by comet assay. Our results showed that lipid profile and liver function parameters are not affected by EGCG and serum levels of vitamin E increased, but not vitamin A. An increase in DNA damage and DNA oxidative damage after 90 days of EGCG consumption was also reported. The results suggest that EGCG can induce DNA damage, possibly due to ROS induction, with an associated increase of the antioxidant vitamin E, however without alteration of hematological cardiovascular risk factors.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLadeira C, Pádua M, Ramos C, Ribeiro E. Green tea epigallocatechin-3-gallate (EGCG) oxidative stress and DNA damage. In: SFRRE Annual Meeting Abstracts - Society for Free Radical Research Europe, “Redox Homeostasis: From Signaling to Damage”, Ferrara (Italy), June 19-21, 2019. Free Radical Biol Med. 2019;139 Suppl 1:S33.pt_PT
dc.identifier.doihttps://doi.org/10.1016/j.freeradbiolmed.2019.05.021pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14380
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/journal/free-radical-biology-and-medicine/vol/139/suppl/S1pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectEpigallocatechin-3-gallatept_PT
dc.subjectGreen teapt_PT
dc.subjectOxidative stresspt_PT
dc.subjectDNA damagept_PT
dc.titleGreen tea epigallocatechin-3-gallate (EGCG) oxidative stress and DNA damagept_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceFerrarapt_PT
person.familyNameLadeira
person.familyNameRibeiro
person.givenNameCarina
person.givenNameEdna
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.ciencia-idC414-CDF2-D35A
person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1316-7750
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublicationa571bf34-bcda-49ca-b5cb-4cdecbb3d9c7
relation.isAuthorOfPublication.latestForDiscoverya571bf34-bcda-49ca-b5cb-4cdecbb3d9c7

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