Repository logo
 
Publication

The pharmacological effect of hemin in inflammatory-related diseases: a systematic review

2024-04Journal article Open access
Simple item page
dc.contributor.authorEstarreja, João
dc.contributor.authorCaldeira, Gonçalo
dc.contributor.authorSilva, Inês
dc.contributor.authorMendes, Priscila
dc.contributor.authorMateus, Vanessa
dc.date.accessioned2024-04-29T12:31:52Z
dc.date.available2024-04-29T12:31:52Z
dc.date.issued2024-04
dc.descriptionThe authors from the Health and Technology Research Center gratefully acknowledge the support of the Fundação para a Ciência e a Tecnologia/Ministério da Ciência, Tecnologia e Ensino Superior (UIDB/05608/2020 and UIDP/05608/2020).pt_PT
dc.description.abstractBackground: Hemin is clinically used in acute attacks of porphyria; however, recent evidence has also highlighted its capability to stimulate the heme oxygenase enzyme, being associated with cytoprotective, antioxidant, and anti-inflammatory effects. Indeed, current preclinical evidence emphasizes the potential anti-inflammatory role of hemin through its use in animal models of disease. Nevertheless, there is no consensus about the underlying mechanism(s) and the most optimal therapeutic regimens. Therefore, this review aims to summarize, analyze, and discuss the current preclinical evidence concerning the pharmacological effect of hemin. Methods: Following the application of the search expression and the retrieval of the articles, only nonclinical studies in vivo written in English were considered, where the potential anti-inflammatory effect of hemin was evaluated. Results: Forty-nine articles were included according to the eligibility criteria established. The results obtained show the preference of using 30 to 50 mg/kg of hemin, administered intraperitoneally, in both acute and chronic contexts. This drug demonstrates significant anti-inflammatory and antioxidant activities considering its capacity for reducing the expression of proinflammatory and oxidative markers. Conclusions: This review highlighted the significant anti-inflammatory and antioxidant effects of hemin, providing a clearer vision for the medical community about the use of this drug in several human diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEstarreja J, Caldeira G, Silva I, Mendes P, Mateus V. The pharmacological effect of hemin in inflammatory-related diseases: a systematic review. Biomedicines. 2024;12(4):898.pt_PT
dc.identifier.doi10.3390/biomedicines12040898pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17403
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2227-9059/12/4/898pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnimal modelspt_PT
dc.subjectHeminpt_PT
dc.subjectInflammationpt_PT
dc.subjectNonclinical studies in vivopt_PT
dc.subjectOxidative stresspt_PT
dc.subjectInflammatory-related diseasespt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.titleThe pharmacological effect of hemin in inflammatory-related diseases: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage898pt_PT
oaire.citation.titleBiomedicinespt_PT
oaire.citation.volume12pt_PT
person.familyNameEstarreja
person.familyNameCaldeira
person.familyNameda Silva
person.familyNameRodrigues Gomes Mendes
person.familyNamePinho Mateus
person.givenNameJoão
person.givenNameGonçalo
person.givenNameInês Filipa Janeiro da Silva
person.givenNamePriscila
person.givenNameVanessa Alexandra
person.identifier.ciencia-idEB19-EDA2-704B
person.identifier.ciencia-idC010-323F-3266
person.identifier.ciencia-id6A16-5C18-F10B
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0002-8283-3174
person.identifier.orcid0009-0006-9605-0118
person.identifier.orcid0000-0001-7049-2512
person.identifier.orcid0000-0002-0013-3140
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationd16a20d0-ac73-4989-b83d-abeab53139f7
relation.isAuthorOfPublication738ba2ba-0df1-4218-b202-2df923090fb9
relation.isAuthorOfPublication995e1831-ff5b-49e7-a6e3-8bc692212204
relation.isAuthorOfPublicationb02faa18-658e-4edc-b846-7c0b3646414c
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscoveryd16a20d0-ac73-4989-b83d-abeab53139f7

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
The pharmacological effect of hemin in inflammatory-related diseases_a systematic review.pdf
Size:
893.79 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos