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Insulin resistance does not play a major role in lipid and apolipoprotein profile in obese women

dc.contributor.authorSilva-Nunes, José
dc.contributor.authorBrito, Miguel
dc.contributor.authorVeiga, Luísa
dc.date.accessioned2015-08-20T14:12:20Z
dc.date.available2015-08-20T14:12:20Z
dc.date.issued2015-05
dc.description.abstractBackground: Obesity is associated with increased atherogenesis through alterations in lipids, among other potential factors. Some of those abnormalities might be mediated by insulin resistance (IR). Aims: To compare lipid and apolipoprotein profile between lean and obese women; to evaluate the influence of IR on lipid and apolipoprotein profile, in obese women. Methods: We studied 112 obese and 100 normal-weight premenopausal women without known cardiovascular disease. Both groups were characterized for anthropometrics and a fasting blood sample was collected for assessment of glucose, insulin, triglycerides, cholesterol (total, LDL and HDL), and apolipoproteins A-I, A-II, B, C-II, C-III, and E; IR was assessed by the homeostatic model assessment (HOMA-IR). We compared lipids between obese and lean women; we looked for correlation of those levels with anthropometrics and IR (independently from anthropometrics) in obese women. Results: Obese women were characterized by mean age=34.6±8.3 years, BMI=43.6±7.9 kg/m2, waist circumference (Wc)=117.5±15.1 cm, and HOMA-IR=4.28±3.5. Lean women (age=34.2±8.3 years, BMI=21.4±1.7 kg/m2, Wc=71.7±5.8 cm, and HOMA-IR=1.21±0.76) presented with significantly lower levels of total cholesterol (P=0.001), LDL-cholesterol (P<0.001), and triglycerides (P<0.001); they presented higher levels of HDL-cholesterol (P<0.001), Apo A-I (P<0.001) and Apo A-II (P=0.037). HOMA-IR showed no significant association with apolipoproteins. HOMA-IR was inversely associated with HDL-cholesterol (P=0.048; r=−0.187) but that association disappeared when we adjusted for waist circumference. Only triglycerides were directly associated with HOMA-IR (P<0.001; r=0.343) independently from anthropometrics. Conclusion: We confirm that obese women present worst lipid and apolipoprotein profile. However, with the exception for triglycerides, insulin resistance per se does not play a major role in lipid and apolipoprotein abnormalities observed in obese women.por
dc.identifier.citationSilva-Nunes J, Brito M, Veiga L. Insulin resistance does not play a major role in lipid and apolipoprotein profile in obese women. IN ECE 2015, Dublin (Ireland), 16-20 May 2015. Endocr Abstr. 2015;37:EP643.por
dc.identifier.doi10.1530/endoabs.37.EP643
dc.identifier.urihttp://hdl.handle.net/10400.21/4881
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherBioScientificapor
dc.relation.publisherversionhttp://www.endocrine-abstracts.org/ea/0037/ea0037ep643.htmpor
dc.subjectInsulin resistancepor
dc.subjectLipidepor
dc.subjectObesitypor
dc.subjectWomenpor
dc.titleInsulin resistance does not play a major role in lipid and apolipoprotein profile in obese womenpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.titleEndocrine Abstractspor
oaire.citation.volume37por
person.familyNameBrito
person.familyNameVeiga
person.givenNameMiguel
person.givenNameLuisa
person.identifier.ciencia-id231F-F341-7E93
person.identifier.ciencia-id9413-918D-DB0E
person.identifier.orcid0000-0001-6394-658X
person.identifier.orcid0000-0003-1153-8343
person.identifier.ridA-7970-2016
person.identifier.ridL-2730-2013
person.identifier.scopus-author-id35224551000
person.identifier.scopus-author-id8318978600
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublicationaac1914a-275f-4be2-819d-ab41d356b45a
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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