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Morbidity associated with schistosomiasis in adult population of Chókwè district, Mozambique

2024-12Journal article Open access
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dc.contributor.authorSerra, João Tiago
dc.contributor.authorSilva, Carina
dc.contributor.authorSidat, Mohsin
dc.contributor.authorBelo, Silvana
dc.contributor.authorFerreira, Pedro
dc.contributor.authorFerracini, Natália
dc.contributor.authorKaminstein, Daniel
dc.contributor.authorThompson, Ricardo
dc.contributor.authorConceiçao, Claúdia
dc.date.accessioned2024-12-23T15:21:46Z
dc.date.available2024-12-23T15:21:46Z
dc.date.issued2024-12
dc.descriptionThis work was funded by the "Joint WHO-AFRO/TDR/EDCTP Small Grants Scheme for Implementation Research on Infectious Diseases of Poverty 2017”, whose responsible investigator was RT. Additionally, it received financial support from “Associação para Desenvolvimento da Medicina Tropical”, whose responsible investigator was JTS. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.pt_PT
dc.description.abstractBackground: Mozambique is one of the countries with the highest prevalence of schistosomiasis, although there is little data on the prevalence of the disease and associated morbidity in the adult population. This study aimed to describe and characterize the morbidity associated with schistosomiasis in the adult population of the Chókwè district and to explore the use of anamnestic questionnaires and urine dipsticks, as well as point-of-care ultrasound for urinary-related findings, to better characterize disease prevalence and morbidity. Methodology: Between April and October 2018, we conducted a cross-sectional study embedded within the Chókwè Health Research and Training Centre. Data were collected on sociodemographic variables, signs and symptoms of schistosomiasis, and water-related activities. Infection status was determined by urine filtration, Kato-Katz thick smear, and DNA detection. Point-of-care urinary tract ultrasonography was performed to assess structural morbidity associated with Schistosoma haematobium infection. Multivariate logistic regression was used to search for associations between risk factors, signs and symptoms, infection status, and ultrasound abnormalities. Principal findings: Our study included 1033 participants with a mean age of 32 years old. The prevalence of Schistosoma haematobium, Schistosoma mansoni, and ultrasound-detected urinary tract abnormalities was 11.3% (95% CI 9.5%-13.4%), 5.7% (95% CI 4.3%-7.5%) and 37.9% (95% CI 34.8%-41.2%), respectively. Of the 37.9% with urinary tract abnormalities, 14.5% were positive for Schistosoma haematobium. Reported hematuria in the last month (p = 0.004, aOR 4.385) and blood in the urine dipstick (p = 0.004, aOR 3.958) were markers of Schistosoma haematobium infection. Reporting lower abdominal pain (p = 0.017, aOR 1.599) was associated with ultrasound abnormalities. Conclusion: Using microscopy and DNA analysis for both Schistosoma haematobium and Schistosoma mansoni in conjunction with urinary ultrasound abnormalities gives us several insights into correlations between disease prevalence (microscopic and anatomical) and demographic details in a high-risk population.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSerra JT, Silva C, Sidat M, Belo S, Ferreira P, Ferracini N, et al. Morbidity associated with schistosomiasis in adult population of Chókwè district, Mozambique. PLoS Negl Trop Dis. 2024;18(12):e0012738.pt_PT
dc.identifier.doi10.1371/journal.pntd.0012738pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/18070
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLoSpt_PT
dc.relation.publisherversionhttps://journals.plos.org/plosntds/article?id=10.1371/journal.pntd.0012738pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPublic healthpt_PT
dc.subjectSchistosomiasispt_PT
dc.subjectMorbiditypt_PT
dc.subjectMozambiquept_PT
dc.subjectChókwè districtpt_PT
dc.titleMorbidity associated with schistosomiasis in adult population of Chókwè district, Mozambiquept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12pt_PT
oaire.citation.startPagee0012738pt_PT
oaire.citation.titlePLOS Neglected Tropical Diseasespt_PT
oaire.citation.volume18pt_PT
person.familyNameSilva
person.givenNameCarina
person.identifier.ciencia-id2411-5936-0820
person.identifier.orcid0000-0003-1021-7935
person.identifier.scopus-author-id55258764900
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication81a5cd80-1982-43ba-bde5-4c43ae0e5234
relation.isAuthorOfPublication.latestForDiscovery81a5cd80-1982-43ba-bde5-4c43ae0e5234

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