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Influence of cigarette smoking on the Index of Cardiac Electrophysiological Balance in apparently healthy Angolans

dc.contributor.authorGonçalves, Mauer
dc.contributor.authorPedro, João Mário
dc.contributor.authorSilva, Carina
dc.contributor.authorMagalhães, Pedro
dc.contributor.authorBrito, Miguel
dc.date.accessioned2024-01-03T12:26:22Z
dc.date.available2024-01-03T12:26:22Z
dc.date.issued2024-01
dc.descriptionThe present study was supported by: Camões, Institute of Cooperation and Language, Portugal; Calouste Gulbenkian Foundation, Portugal; Government of Bengo Province, Angola; and the Angolan Ministry of Health.pt_PT
dc.description.abstractBackground: Tobacco use accelerates atherosclerosis and is one of the predictors of death from ischemic heart disease, arrhythmias, heart failure, and sudden death. A new non-invasive parameter, the Index of Cardiac Electrophysiological Balance (iCEB) between depolarization and repolarization of the action potential, was considered a new biomarker for the identification of patients at increased arrhythmic risk. Objectives: We aimed to evaluate the iCEB in apparently healthy Angolans with habitual cigarette smoking compared to non-smokers. Subjects and methods: Data were obtained from the CardioBengo study, a cross-sectional community-based study in which a random sample of individuals aged between 15 and 84 years was selected. In total, 214 healthy subjects, 102 smokers, and 112 non-smokers in the same age group were included in the final analysis. Results: The average age of the participants was 42.17±13.04 years old and 26.6% of the sample was female. Smoking subjects had higher iCEB and corrected Index of Cardiac Electrophysiological Balance (iCEBc) values compared with non-smoking controls (4.39 vs. 4.25; p=0.024, respectively), and (4.74 vs. 4.57; p=0.030, respectively). Conclusions: In summary, iCEB and iCEBc were significantly higher in habitual smokers than in nonsmokers, which represents an increased risk of ventricular arrhythmogenesis in healthy habitual smokers. To the best of our knowledge, this is the first study performed in Africa to evaluate iCEB in smokers, making this type of study very important in low- and middle-income countries in the context of epidemiological transition.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves M, Pedro JM, Silva C, Magalhães P, Brito M. Influence of cigarette smoking on the Index of Cardiac Electrophysiological Balance in apparently healthy Angolans. Global Cardiol Sci Pract. 2024;2024(1):e202405.pt_PT
dc.identifier.doi10.21542/gcsp.2024.5pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16751
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMagdi Yacoub Insitutept_PT
dc.relation.publisherversionhttps://globalcardiologyscienceandpractice.com/index.php/gcsp/article/view/653pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectIndex of Cardiac Electrophysiological Balancept_PT
dc.subjectSmokingpt_PT
dc.subjectAngolapt_PT
dc.titleInfluence of cigarette smoking on the Index of Cardiac Electrophysiological Balance in apparently healthy Angolanspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue1pt_PT
oaire.citation.startPagee202405pt_PT
oaire.citation.titleGlobal Cardiology Science and Practicept_PT
oaire.citation.volume2024pt_PT
person.familyNameSilva
person.familyNameBrito
person.givenNameCarina
person.givenNameMiguel
person.identifier.ciencia-id2411-5936-0820
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0003-1021-7935
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id55258764900
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication81a5cd80-1982-43ba-bde5-4c43ae0e5234
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery81a5cd80-1982-43ba-bde5-4c43ae0e5234

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