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Ecosapentanoic acid (EPA) does not affect cell kinetics in peripheral lymphocites from patients with Crohn's disease (CD) according to IL6 174G/C polymorphism

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dc.contributor.authorBrito, Miguel
dc.contributor.authorFerreira, Paula
dc.contributor.authorGuerreiro, Catarina Sousa
dc.contributor.authorMalta-Vacas, Joana
dc.contributor.authorTavares, L.
dc.contributor.authorSantos, P.
dc.contributor.authorPinto, A.
dc.contributor.authorCravo, Marília
dc.date.accessioned2014-03-12T16:05:05Z
dc.date.available2014-03-12T16:05:05Z
dc.date.issued2008
dc.description.abstractRationale: Omega 3 fatty acids have been shown to be of potential benefit in patients with CD. The aim of the present study was to evaluate whether EPA can modulate the inflammatory response according to different genotypes of IL6G174G/C polymorphism. Methods: Peripheral blood cells were collected from CD patients with different genotypes for IL6 174G/C (GG, n = 16, GC, n = 8, CC, n = 7), and lymphocytes were established in culture media. Replicates with the addition of EPA (25 mM) were analysed in a period of 24h, 48h and 72h. Expression of IL6 e a PGE2 was assessed by ELISA. Apoptosis and cellular proliferation was determined by flow cytometry.por
dc.identifier.citationBrito M, Ferreira P, Guerreiro CS, Malta-Vacas J, Tavares L, Santos P, et al. Ecosapentanoic acid (EPA) does not affect cell kinetics in peripheral lymphocites from patients with Crohn's disease (CD) according to IL6 174G/C polymorphism. Clin Nutr Suppl. 2008;3 Suppl 1:53.por
dc.identifier.otherDOI:10.1016/S1744-1161(08)70119-4
dc.identifier.urihttp://hdl.handle.net/10400.21/3364
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.clinicalnutritionsupplements.com/article/S1744-1161%2808%2970119-4/abstractpor
dc.subjectCrohn diseasepor
dc.subjectEcosapentanoic acidpor
dc.subjectGenotypespor
dc.subjectIL6 174 CCpor
dc.titleEcosapentanoic acid (EPA) does not affect cell kinetics in peripheral lymphocites from patients with Crohn's disease (CD) according to IL6 174G/C polymorphismpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.endPage53por
oaire.citation.startPage53por
oaire.citation.titleClinical Nutrition. Supplementpor
oaire.citation.volume3por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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