Repository logo
 
Publication

Next-generation wound care: a scoping review on probiotic, prebiotic, synbiotic, and postbiotic cutaneous formulations

2025-05Journal article Open access
Simple item page
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorMachado, Patrícia
dc.contributor.authorRibeiro, Felipe Neme
dc.contributor.authorGiublin, Fernanda Wroblevski
dc.contributor.authorMieres, Naomi Gerzvolf
dc.contributor.authorTonin, Fernanda
dc.contributor.authorPontarolo, Roberto
dc.contributor.authorSari, Marcel Marcondes
dc.contributor.authorLazo, Raul Luna
dc.contributor.authorFerreira, Luana Mota
dc.date.accessioned2025-06-04T14:54:39Z
dc.date.available2025-06-04T14:54:39Z
dc.date.issued2025-05
dc.descriptionThis research was funded by CNPq and the fellowship was received by Raul Edison Luna Lazo (grant #176655/2023-9). This study is part of the National Institute of Science and Technology in 3D printing and Advanced Materials Applied to Human and Veterinary Health—INCT_3D-Saúde, funded by CNPq, Brazil (Grant #406436/2022-3).
dc.description.abstractBackground/Objectives: Chronic wounds represent a significant socioeconomic burden, affecting 1–2% of the global population. Wound healing is a complex process involving inflammation, cell proliferation, and tissue remodeling, but factors such as infections, diabetes, aging, and poor nutrition can impair recovery, leading to chronic wounds. Given these challenges, researchers have explored topical probiotics, synbiotics, and postbiotics as alternative strategies. Strains like Lactobacillus and Bifidobacterium contribute to skin restoration by producing antimicrobial, anti-inflammatory, and immunomodulatory compounds, offering a novel approach to cutaneous restoration. Our study aims to address the potential effects of topical probiotic, synbiotic, and postbiotic formulations for wound healing applications by means of a broad scoping review and evidence-gap mapping. Methods: A systematic literature search of preclinical studies (in vitro and in vivo) was performed in PubMed, Scopus, and Web of Science (January 2025), yielding 3052 articles after duplicates removal, of which 44 met the inclusion criteria. Results: These studies were published between 1986 and 2024, mostly by China (27.3%) and Iran (25.0%). Probiotics were frequently evaluated among the studies included (47.7%) (with Lactobacillus plantarum being the most assessed strain), followed by postbiotics (36.4%) (with predominant use of cell-free supernatants) and synbiotics (15.9%) (especially fructooligosaccharides). Dosage forms included gels (44.4%), films (15.6%), and ointments (13.3%). Conclusions: Most studies indicate that probiotics, synbiotics, and postbiotics have antimicrobial and anti-inflammatory properties, while promoting angiogenesis, tissue regeneration, and skin barrier restoration. The use of different delivery systems may additionally enhance therapeutic outcomes by accelerating wound closure, reducing bacterial load, and modulating immune response. However, methodological limitations in animal studies highlight the need for greater experimental rigor. Further robust clinical trials are essential to confirm efficacy and safety before clinical application of these formulations.eng
dc.identifier.citationMachado P, Ribeiro FN, Giublin FW, Mieres NG, Tonin FS, Pontarolo R, et al. Next-generation wound care: a scoping review on probiotic, prebiotic, synbiotic, and postbiotic cutaneous formulations. Pharmaceuticals (Basel). 2025;18(5):704.
dc.identifier.doi10.3390/ph18050704
dc.identifier.issn1424-8247
dc.identifier.urihttp://hdl.handle.net/10400.21/21904
dc.language.isoeng
dc.peerreviewedyes
dc.publisherMDPI AG
dc.relation.hasversionhttps://www.mdpi.com/1424-8247/18/5/704
dc.relation.ispartofPharmaceuticals
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectBurned skin
dc.subjectCutaneous administration
dc.subjectDermatological formulations
dc.subjectExcisional skin
dc.subjectScar formation
dc.subjectTissue repair
dc.titleNext-generation wound care: a scoping review on probiotic, prebiotic, synbiotic, and postbiotic cutaneous formulationseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue5
oaire.citation.startPage704
oaire.citation.titlePharmaceuticals
oaire.citation.volume18
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Next-generation wound care_a scoping review on probiotic, prebiotic, synbiotic, and postbiotic cutaneous formulations.pdf
Size:
2.2 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos