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eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development

2009-06Journal article Open access
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dc.contributor.authorMalta-Vacas, Joana
dc.contributor.authorChauvin, Celine
dc.contributor.authorGonçalves, Lucília
dc.contributor.authorNazaré, Antónia
dc.contributor.authorCarvalho, Carlos
dc.contributor.authorMonteiro, Carolino
dc.contributor.authorBagrel, Denyse
dc.contributor.authorJean-Jean, Olivier
dc.contributor.authorBrito, Miguel
dc.date.accessioned2014-01-04T18:08:05Z
dc.date.available2014-01-04T18:08:05Z
dc.date.issued2009-06
dc.description.abstractIt is now widely recognized that translation factors are involved in cancer development and that components of the translation machinery that are deregulated in cancer cells may become targets for cancer therapy. The eukaryotic Release Factor 3 (eRF3) is a GTPase that associates with eRF1 in a complex that mediates translation termination. eRF3a/GSPT1 first exon contains a (GGC)n expansion coding for proteins with different N-terminal extremities. Herein we show that the longer allele (12-GGC) is present in 5.1% (7/137) of the breast cancer patients analysed and is absent in the control population (0/135), corresponding to an increased risk for cancer development, as revealed by Odds Ratio analysis. mRNA quantification suggests that patients with the 12-GGC allele overexpress eRF3a/GSPT1 in tumor tissues relative to the normal adjacent tissues. However, using an in vivo assay for translation termination in HEK293 cells, we do not detect any difference in the activity of the eRF3a proteins encoded by the various eRF3a/GSPT1 alleles. Although the connection between the presence of eRF3a/GSPT1 12-GGC allele and tumorigenesis is still unknown, our data suggest that the presence of the 12-GGC allele provides a potential novel risk marker for various types of cancer.por
dc.identifier.citationMalta-Vacas J, Chauvin C, Gonçalves L, Nazaré A, Carvalho C, Brito M, et al. eRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer development. Oncol Rep. 2009;21(6):1551-8.por
dc.identifier.issn1791-2431
dc.identifier.urihttp://hdl.handle.net/10400.21/3072
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherSpandidos Publicationspor
dc.relation.publisherversionhttp://www.spandidos-publications.com/or/21/6/1551por
dc.subjectBreast neoplasmspor
dc.subjectCase-control studiespor
dc.subjectCell line, Tumorpor
dc.subjectGene frequencypor
dc.subjectGenetic predisposition to diseasepor
dc.subjectOdds ratiopor
dc.subjectPeptide termination factorspor
dc.subjectPolymorphism, Geneticpor
dc.subjectRNA interferencepor
dc.subjectRisk assessmentpor
dc.subjectRisk factorpor
dc.titleeRF3a/GSPT1 12-GGC allele increases the susceptibility for breast cancer developmentpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1558por
oaire.citation.startPage1551por
oaire.citation.titleOncology Reportspor
oaire.citation.volume21por
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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