The recycling of tubulin heterodimer by tubulin cofactors TBCA, TBCB, and TBCE is blocked by colchicine

Nolasco, Sofia; Bellido, J.; Serna, M.; Carmona, Bruno; Soares, Helena; Zabala, J.

http://hdl.handle.net/10400.21/15215

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Abstract(s)

Colchicine has been used to treat gout and effectively prevent autoinflammatory diseases and primary and recurrent pericarditis episodes. The anti-inflammatory action of colchicine seems to result from compromised microtubule (MT) networks that affect several inflammatory pathways in cells that mediate immune response like the entire NLRP3 inflammasome.

Keywords

Tubulin Colchicine Inflammatory disease

URI

http://hdl.handle.net/10400.21/15215

Citation

Nolasco S, Bellido J, Serna M, Carmona B, Soares H, Zabala J. The recycling of tubulin heterodimer by tubulin cofactors TBCA, TBCB, and TBCE is blocked by colchicine. In: 2021 ASCB Annual Meeting abstracts. Mol Biol Cell. 2021;32(22):poster 843.