Repository logo
 
Publication

Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2/TLR4-activated dendritic cells

2025-06Journal article Open access
Simple item page
datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorZúquete, Sara
dc.contributor.authorFerreira, Mariana
dc.contributor.authorDelgado, Inês L.
dc.contributor.authorRosa, Maria teresa
dc.contributor.authorMendes, Ana Catarina
dc.contributor.authorSantos, Dulce
dc.contributor.authorNolasco, Sofia
dc.contributor.authorGraça, Luís
dc.contributor.authorLeitão, Alexandre
dc.contributor.authorBasto, Afonso P.
dc.date.accessioned2025-07-02T10:37:06Z
dc.date.available2025-07-02T10:37:06Z
dc.date.issued2025-06
dc.descriptionThis work was funded by Fundação para a Ciência e Tecnologia (FCT, Portugal) through the projects grants PTDC/CVT-CVT/31840/2017, PTDC/CVT-CVT/4599/2021, 2022.04903.PTDC, LA/P/0059/2020 (AL4AnimalS), and UID/CVT/00276/2019 and UIDB/00276/2020 (CIISA). Funding was also provided by Fundación la Caixa through the project HR22-00741.
dc.description.abstractToll-like receptor (TLR)2 activation induces aldehyde dehydrogenase enzymes in non-mucosal dendritic cells (DCs), enabling them to metabolize vitamin A into all-trans retinoic acid, which induces the expression of mucosal-homing molecules (α4β7 and CCR9) in the activated T cells. Recently, we have shown that the simultaneous activation of non-mucosal DCs through TLR2 and TLR4 maintains such capacity while reinforcing the polarization of primed CD4+ T cells towards Th1. Here, we observed that TLR2/TLR4 stimulation of aged DCs leads to the production of less TNFα and more IL-10, and that CD4+ T cells primed by those DCs express lower levels of the mucosal homing receptor CCR9 and produce less type-1 (IFNγ) and more type-2 (IL-4 and IL-13) cytokines. These results emphasize the importance of considering the age-related alterations in DC function when developing novel immunomodulation strategies that rely on the DC-T cell crosstalk through stimulation of pattern recognition receptors.eng
dc.identifier.citationZúquete S, Ferreira M, Delgado IL, Rosa MT, Mendes AC, Nolasco S, et al. Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2/TLR4-activated dendritic cells. J Leukoc Biol. 2025:qiaf096. DOI: 10.1093/jleuko/qiaf096. Epub ahead of print.
dc.identifier.doi10.1093/jleuko/qiaf096
dc.identifier.issn1938-3673
dc.identifier.urihttp://hdl.handle.net/10400.21/21944
dc.language.isoeng
dc.peerreviewedyes
dc.publisherOxford University Press (OUP)
dc.relation.hasversionhttps://academic.oup.com/jleukbio/advance-article/doi/10.1093/jleuko/qiaf096/8176515?login=true
dc.relation.ispartofJournal of Leukocyte Biology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectToll-like receptor 2
dc.subjectToll-like receptor 4
dc.subjectAgeing
dc.subjectDendritic cells
dc.subjectIntestine
dc.titleAgeing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2/TLR4-activated dendritic cellseng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleJournal of Leukocyte Biology
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameNolasco
person.givenNameSofia
person.identifier.ciencia-id5017-368D-3F71
person.identifier.orcid0000-0003-2168-0511
relation.isAuthorOfPublication34a552a4-6414-461d-a5f6-862a175ea812
relation.isAuthorOfPublication.latestForDiscovery34a552a4-6414-461d-a5f6-862a175ea812

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ageing affects the CD4+ T cell polarization and mucosal tropism induced by TLR2_TLR4-activated dendritic cells.pdf
Size:
839.82 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
4.03 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos