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A comprehensive approach to evaluate nutritional status in Crohn's patients in the era of biologic therapy: a case-control study

2007-11Journal article Open access
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dc.contributor.authorGuerreiro, Catarina Sousa
dc.contributor.authorCravo, Marília
dc.contributor.authorCosta, Ana Raimundo
dc.contributor.authorMiranda, Ana
dc.contributor.authorTavares, Lourdes
dc.contributor.authorSantos, Paula Moura dos
dc.contributor.authorVidal, Pedro Marques
dc.contributor.authorLeitão, Carlos Nobre
dc.date.accessioned2014-01-02T17:31:28Z
dc.date.available2014-01-02T17:31:28Z
dc.date.issued2007-11
dc.description.abstractObjectives - Evaluate the nutritional status of patients with inactive or mildly active Crohn's disease (CD), and identify possible causes for potential deficiencies. Methods - A total of 78 CD patients and 80 healthy controls were evaluated in respect of nutritional status, dietary intake, and life styles factors. Results - These 73/78 CD patients were on immunomodulating therapies. Mean body mass index (BMI) was lower in patients as compared to controls (P= 0.006) but 32% of CD patients and 33.8% of controls had a BMI > 25, whereas 8% and 23.8% in each group, respectively, were obese (BMI > 30Kg/m(2)). Fat free mass was significantly decreased in both genders (P < 0.05) whereas fat mass was decreased only in males (P= 0.01). Energy intake was significantly lower in CD patients (P < 0.0001) and we observed significantly lower adjusted mean daily intakes of carbohydrates, monounsaturated fat, fiber, calcium, and vitamins C, D, E, and K (P < 0.05). 29% of patients had excluded grains from their usual diet, 28% milk, 18% vegetables, and 11% fruits. Milk exclusion resulted in a significantly lower consumption of calcium and vitamin K (P < 0.001) and the exclusion of vegetables was associated to a lower consumption of vitamins C and E (P < 0.05). Physical activity was significantly lower in CD patients (P= 0.01) and this lack of physical activity was inversely correlated with increased fat mass percentage (r=-0.315, P= 0.001). Conclusions - Results showed that the most prevalent form of malnutrition in CD patients was an excess of body weight, which was concomitant with an inadequate dietary intake, namely micronutrients, clearly related to dietary exclusion of certain foods.por
dc.identifier.citationGuerreiro CS, Cravo M, Costa AR, Miranda A, Tavares L, Santos PM, et al. A comprehensive approach to evaluate nutritional status in Crohn's patients in the era of biologic therapy: a case-control study. Am J Gastroenterol. 2007;102(11):2551-6.por
dc.identifier.issn1572-0241
dc.identifier.urihttp://hdl.handle.net/10400.21/3055
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherNaturepor
dc.relation.publisherversionhttp://www.nature.com/ajg/journal/v102/n11/full/ajg2007493a.htmlpor
dc.subjectAnalysis of variancepor
dc.subjectBody mass indexpor
dc.subjectCase-control studiespor
dc.subjectChi-square distributionpor
dc.subjectCrohn diseasepor
dc.subjectEnergy intakepor
dc.subjectLife stylepor
dc.subjectNutrition disorderspor
dc.subjectNutritional statuspor
dc.subjectRisk factorpor
dc.subjectPortugalpor
dc.titleA comprehensive approach to evaluate nutritional status in Crohn's patients in the era of biologic therapy: a case-control studypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2556por
oaire.citation.startPage2551por
oaire.citation.titleAmerican Journal of Gastroenterologypor
oaire.citation.volume102por
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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