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Integration of effect biomarkers in human biomonitoring

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dc.contributor.authorLadeira, Carina
dc.date.accessioned2024-08-29T11:33:15Z
dc.date.available2024-08-29T11:33:15Z
dc.date.issued2024-06
dc.descriptionH&TRC author gratefully acknowledges the FCT/MCTES national support through the UIDP/05608/2020, UIDB/05608/2020, and IPL/2021/PLASCOGEN_ESTeSL.pt_PT
dc.description.abstractHuman biomonitoring is an important tool for assessing exposure to chemicals and their health risks. Once human internal exposure to a chemical is shown, the complementary use of effect biomarkers can help bridge health consequences by providing data on pre-clinical manifestations of disease with a probability of being prevented. Effect biomarkers that measure genetic damage are potent tools to address the carcinogenic and/or mutagenic potential of chemical exposures, increasing confidence in regulatory risk assessment decision-making processes. The micronucleus (MN) test is recognized as one of the most successful and reliable assays to assess genotoxic events, which are associated with exposures that may cause cancer. There is fair evidence of a significant increase in MN frequency in patients with cancer and other chronic diseases compared with controls, substantiating its predictive value. Promising approaches, such as combined effect biomarkers open the possibility to evaluate the combined effects of complex chemical mixtures in human samples, and efforts are needed to integrate these approaches in risk assessment. Although effect biomarkers are gaining ground in human biomonitoring, new challenges are still arising. To move towards the next generation of human risk assessment is crucial to establish bridges between standard approaches of effect biomarkers and new approach methods (NAMs) and tools for increasing the mechanistically-based biological plausibility in human studies, such as the adverse outcome pathways (AOPs) framework. Human epidemiological studies with biomarkers of effect play an invaluable role in identifying the health effects of chemical exposures and may provide a tool for improving risk assessment and may be especially useful in the case of risk assessment of chemical mixtures.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLadeira C. Integration of effect biomarkers in human biomonitoring. In: SEMA 2024 – 28th Spanish Environmental Mutagenesis and Genomics Society meeting, Vila Real (Portugal), June 26-28, 2024. Span J Environ Mutagen Genom. 2024;28(1):9.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17640
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationIPL/2021/PLASCOGEN_ESTeSLpt_PT
dc.relation.publisherversionhttps://ojs.diffundit.com/index.php/sema/issue/view/93pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectHuman biomonitoringpt_PT
dc.subjectEffect biomarkerspt_PT
dc.subjectIPL/2021/PLASCOGEN_ESTeSLpt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.titleIntegration of effect biomarkers in human biomonitoringpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceVila Realpt_PT
person.familyNameLadeira
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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