Repository logo
 
Publication

Approaches to tuberculosis mucosal vaccine development using nanoparticles and microparticles: a review

2014-09Journal article Open access
Simple item page
dc.contributor.authorCaetano, Liliana Aranha
dc.contributor.authorAlmeida, António José
dc.contributor.authorGonçalves, Lídia Maria Diogo
dc.date.accessioned2015-12-15T12:13:10Z
dc.date.available2015-12-15T12:13:10Z
dc.date.issued2014-09
dc.description.abstractNext-generation vaccines for tuberculosis should be designed to prevent the infection and to achieve sterile eradication of Mycobacterium tuberculosis. Mucosal vaccination is a needle-free vaccine strategy that provides protective immunity against pathogenic bacteria and viruses in both mucosal and systemic compartments, being a promising alternative to current tuberculosis vaccines. Micro and nanoparticles have shown great potential as delivery systems for mucosal vaccines. In this review, the immunological principles underlying mucosal vaccine development will be discussed, and the application of mucosal adjuvants and delivery systems to the enhancement of protective immune responses at mucosal surfaces will be reviewed, in particular those envisioned for oral and nasal routes of administration. An overview of the essential vaccine candidates for tuberculosis in clinical trials will be provided, with special emphasis on the potential different antigens and immunization regimens.pt_PT
dc.identifier.citationCaetano LA, Almeida AJ, Gonçalves LM. Approaches to tuberculosis mucosal vaccine development using nanoparticles and microparticles: a review. J Biomed Nanotechnol. 2014;10(9):2295-316.pt_PT
dc.identifier.doi10.1166/jbn.2014.1984pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/5408
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Scientific Publisherspt_PT
dc.relation.publisherversionhttp://www.ingentaconnect.com/content/asp/jbn/2014/00000010/00000009/art00026pt_PT
dc.subjectMucosal immunitypt_PT
dc.subjectMicroparticlespt_PT
dc.subjectNanoparticlespt_PT
dc.subjectTuberculosispt_PT
dc.subjectVaccinationpt_PT
dc.subjectVaccine delivery systemspt_PT
dc.subjectImmunitypt_PT
dc.titleApproaches to tuberculosis mucosal vaccine development using nanoparticles and microparticles: a reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage2316pt_PT
oaire.citation.startPage2295pt_PT
oaire.citation.titleJournal of Biomedical Nanotechnologypt_PT
oaire.citation.volume10pt_PT
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Approaches to tuberculosis mucosal vaccine development using nanoparticles and microparticles.pdf
Size:
145.78 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ESTeSL - Artigos