| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 663.57 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Formaldehyde is classified by IARC as carcinogenic to humans (nasopharyngeal cancer). Tobacco smoke has been epidemiologically associated to a higher risk of development of cancer, especially in the oral cavity, larynx and lungs, as these are places of direct contact with many carcinogenic tobacco’s compounds. XRCC3 is involved in homologous recombination repair of cross-links and chromosomal double-strand breaks (Thr241Met polymorphism). The aim of the study is to determine whether there is an in vivo association between genetic polymorphism of the gene XRCC3 and the frequency of genotoxicity biomarkers in subjects exposed or not to formaldehyde and with or without tobacco consumption.
Description
Keywords
Anatomia patológica Saúde ocupacional Formaldeído Tabagismo Consumo de álcool Factor de risco
Citation
Ladeira C, Gomes MC, Brito M. Interaction of formaldehyde and tobacco smoking in the frequency of micronucleus and the XRCC3 Thr241Met polymorphism. In 8th International Symposium on Biological Monitoring in Occupational and Environmental Health, Finland, 6th September 2010. Oral presentation.