Chitosan nanoparticles loaded with minocycline targeting osteomyelitis

Zegre, Miguel; Bastron, S.; Ribeiro, I. A.; Caetano, Liliana Aranha; Gonçalves, L.; Bettencourt, A.

http://hdl.handle.net/10400.21/15136

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Authors

Zegre, Miguel

Bastron, S.

Ribeiro, I. A.

Caetano, Liliana Aranha

Gonçalves, L.

Bettencourt, A.

Abstract(s)

Effective control of osteomyelitis (bone infection) with reduced toxicity is a current challenge. Targeted and controlled drug delivery systems allow: decreased toxicity, upgraded drug targeting, and improved therapeutic effect. Strategy: a) Innovative chitosan nanoparticulate system: nanoparticles loaded with minocycline (antibacterial), and alternative as a local delivery system; b) Nanoparticles and biofilms: advantages: enhanced bioavailability, targeted delivery of antibiotics magnification, local release of antibiotics, controlled and sustained release, and protection against deactivating enzymes.

Keywords

Osteomyelitis Chitosan Nanoparticles

URI

http://hdl.handle.net/10400.21/15136

Citation

Zegre M, Bastron S, Ribeiro IA, Caetano LA, Gonçalves L, Bettencourt A. Chitosan nanoparticles loaded with minocycline targeting osteomyelitis. In: Simposio Iberoamericano COIFFA-2022 [online], Mexico, November 18-19, 2022.