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Zinc deficiency interacts with intestinal/urogenital parasites in the pathway to anemia in preschool children, Bengo-Angola

2022-03Journal article Open access
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dc.contributor.authorFançony, Cláudia
dc.contributor.authorSoares, Ânia
dc.contributor.authorLavinha, João
dc.contributor.authorBrito, Miguel
dc.date.accessioned2022-03-28T12:43:38Z
dc.date.available2022-03-28T12:43:38Z
dc.date.issued2022-03
dc.description.abstractIn host organisms with normal micronutrient status, nutritional immunity is a strongly regulated response aiming at decreasing the progression and severity of infections. Zinc deficiency may disturb this balance, impairing immune responses to infections, which may indirectly increase infection-related anemia. Since zinc deficiency may associate directly with anemia, the role of infections is often overlooked. Herein, we investigated the participation of infections (or inflammation) in the causal pathway between zinc deficiency and anemia. This transversal study, conducted in 2015 in Bengo-Angola, enrolled 852 under-3-year-old children. Logistic regression models were used to investigate the interaction and mediation effects, and significance was confirmed by the Sobel test. In sum, 6.8% of children had zinc deficiency, 45.9% had anemia, and 15.6% had at least one intestinal/urogenital parasite. Furthermore, we found (1) no evidence that inflammation mediates or interacts with zinc deficiency to cause anemia, and (2) zinc deficiency interacts with infections, significantly increasing the odds of anemia (OR: 13.26, p = 0.022). This interaction was stronger among children with iron deficiency anemia (OR: 46.66, p = 0.003). Our results suggest that zinc deficiency may impair the immune response to infections and/or those intestinal parasites could have developed mechanisms to avoid zinc-limited environments. Further studies are needed to corroborate these suggestions.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationFançony C, Soares A, Lavinha J, Brito M. Zinc deficiency interacts with intestinal/urogenital parasites in the pathway to anemia in preschool children, Bengo-Angola. Nutrients. 2022;14(7):1392.pt_PT
dc.identifier.doi10.3390/nu14071392pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14526
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2072-6643/14/7/1392pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectZinc deficiencypt_PT
dc.subjectAnemiapt_PT
dc.subjectInfectionspt_PT
dc.subjectInflammationpt_PT
dc.subjectAngolapt_PT
dc.subjectProvíncia do Bengopt_PT
dc.titleZinc deficiency interacts with intestinal/urogenital parasites in the pathway to anemia in preschool children, Bengo-Angolapt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.startPage1392pt_PT
oaire.citation.titleNutrientspt_PT
oaire.citation.volume14pt_PT
person.familyNameLavinha
person.familyNameBrito
person.givenNameJoão
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0002-7474-6871
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id7003267447
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication619638e0-0ac6-4d52-9f79-e89231278626
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery619638e0-0ac6-4d52-9f79-e89231278626

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