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Chemical constituents, anticancer and anti-proliferative potential of limonium species: a systematic review

2023-02Journal article Open access
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dc.contributor.authorGancedo, Naiara Cássia
dc.contributor.authorIsolani, Raquel
dc.contributor.authorOliveira, Natalia Castelhano de
dc.contributor.authorNakamura, Celso Vataru
dc.contributor.authorAraújo, Daniela Cristina Medeiros
dc.contributor.authorSanches, Andreia Cristina Conegero
dc.contributor.authorTonin, Fernanda
dc.contributor.authorFernandez-Llimos, Fernando
dc.contributor.authorChierrito, Danielly
dc.contributor.authorMello, João Carlos Palazzo de
dc.date.accessioned2023-03-02T10:34:10Z
dc.date.available2023-03-02T10:34:10Z
dc.date.issued2023-02
dc.description.abstractLimonium species represent a source of bioactive compounds that have been widely used in folk medicine. This study aimed to synthesize the anticancer and anti-proliferative potential of Limonium species through a systematic review. Searches were performed in the electronic databases PubMed/MEDLINE, Scopus, and Scielo and via a manual search. In vivo or in vitro studies that evaluated the anticancer or anti-proliferative effect of at least one Limonium species were included. In total, 942 studies were identified, with 33 articles read in full and 17 studies included for qualitative synthesis. Of these, 14 (82.35%) refer to in vitro assays, one (5.88%) was in vivo, and two (11.76%) were designed as in vitro and in vivo assays. Different extracts and isolated compounds from Limonium species were evaluated through cytotoxic analysis against various cancer cell lines (especially hepatocellular carcinoma—HepG2; n = 7, 41.18%). Limonium tetragonum was the most evaluated species. The possible cellular mechanism involved in the anticancer activity of some Limonium species included the inhibition of enzymatic activities and expression of matrix metalloproteinases (MMPs), which suggested anti-metastatic effects, anti-melanogenic activity, cell proliferation inhibition pathways, and antioxidant and immunomodulatory effects. The results reinforce the potential of Limonium species as a source for the discovery and development of new potential cytotoxic and anticancer agents. However, further studies and improvements in experimental designs are needed to better demonstrate the mechanism of action of all of these compounds.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGancedo NC, Isolani R, Oliveira NC, Nakamura CV, Araújo DC, Tonin FS, et al. Chemical constituents, anticancer and anti-proliferative potential of limonium species: a systematic review. Pharmaceuticals. 2023;16(2):293.pt_PT
dc.identifier.doi10.3390/ph16020293pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15742
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1424-8247/16/2/293pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAntitumor activitypt_PT
dc.subjectCytotoxicitypt_PT
dc.subjectMetastasispt_PT
dc.subjectPhytochemicalspt_PT
dc.subjectPlumbaginaceaept_PT
dc.subjectQualitative synthesispt_PT
dc.titleChemical constituents, anticancer and anti-proliferative potential of limonium species: a systematic reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue2pt_PT
oaire.citation.startPage293pt_PT
oaire.citation.titlePharmaceuticalspt_PT
oaire.citation.volume16pt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

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