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Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies

2023-06Journal article Open access
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dc.contributor.authorToigo, Larissa
dc.contributor.authorTeodoro, Emilly Isabelli dos Santos
dc.contributor.authorGuidi, Ana Carolina
dc.contributor.authorGancedo, Naiara Cássia
dc.contributor.authorPetruco, Marcus Vinícius
dc.contributor.authorMelo, Eduardo Borges
dc.contributor.authorTonin, Fernanda
dc.contributor.authorFernandez-Llimos, Fernando
dc.contributor.authorChierrito, Danielly
dc.contributor.authorMello, João Carlos Palazzo de
dc.contributor.authorAraújo, Daniela Cristina de Medeiros
dc.contributor.authorSanches, Andréia Cristina Conegero
dc.date.accessioned2023-05-22T11:57:17Z
dc.date.available2023-05-22T11:57:17Z
dc.date.issued2023-06
dc.descriptionCorreção em https://doi.org/10.1007/s40199-023-00469-9pt_PT
dc.description.abstractObjectives: This scoping review aims to present flavonoid compounds' promising effects and possible mechanisms of action on potential therapeutic targets in the SARS-CoV-2 infection process. Methods: A search of electronic databases such as PubMed and Scopus was carried out to evaluate the performance of substances from the flavonoid class at different stages of SARS-CoV-2 infection. Results: The search strategy yielded 382 articles after the exclusion of duplicates. During the screening process, 265 records were deemed as irrelevant. At the end of the full-text appraisal, 37 studies were considered eligible for data extraction and qualitative synthesis. All the studies used virtual molecular docking models to verify the affinity of compounds from the flavonoid class with crucial proteins in the replication cycle of the SARS-CoV-2 virus (Spike protein, PLpro, 3CLpro/ MPro, RdRP, and inhibition of the host's ACE II receptor). The flavonoids with more targets and lowest binding energies were: orientin, quercetin, epigallocatechin, narcissoside, silymarin, neohesperidin, delphinidin-3,5-diglucoside, and delphinidin-3-sambubioside-5-glucoside. Conclusion: These studies allow us to provide a basis for in vitro and in vivo assays to assist in developing drugs for the treatment and prevention of COVID-19.pt_PT
dc.description.sponsorshipThis study was supported by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) and Conselho Nacional de Desenvolvimento Científco e Tecnológico (CNPq). We would like to thank the Programa de Graduação em Ciências Farmacêuticas at Universidade Estadual do Oeste do Paraná, Universidade Estadual de Maringá, Centro Universitário Ingá, Universidade do Porto and Universidade Federal do Paraná.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationToigo L, Teodoro EI, Guidi AC, Gancedo NC, Petruco MV, Tonin FS, et al. Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies. Daru. 2023;31(1):51-68.pt_PT
dc.identifier.doi10.1007/s40199-023-00461-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/16096
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s40199-023-00461-3pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectCoronaviruspt_PT
dc.subjectFlavonoidspt_PT
dc.subjectIn silicopt_PT
dc.subjectRespiratory syndromept_PT
dc.titleFlavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage68pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage51pt_PT
oaire.citation.titleDARU Journal of Pharmaceutical Sciencespt_PT
oaire.citation.volume31pt_PT
person.familyNameTonin
person.givenNameFernanda
person.identifier.ciencia-idD01C-C700-9411
person.identifier.orcid0000-0003-4262-8608
person.identifier.ridO-2050-2017
person.identifier.scopus-author-id56085115800
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication61ded30e-ecec-4b3e-b953-2293e080ebdd
relation.isAuthorOfPublication.latestForDiscovery61ded30e-ecec-4b3e-b953-2293e080ebdd

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