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HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

2022-03Journal article Open access
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dc.contributor.authorSantonen, Tiina
dc.contributor.authorPorras, Simo P.
dc.contributor.authorBocca, Beatrice
dc.contributor.authorBousoumah, Radia
dc.contributor.authorDuca, Radu Corneliu
dc.contributor.authorGalea, Karen S.
dc.contributor.authorGodderis, Lode
dc.contributor.authorGöen, Thomas
dc.contributor.authorHardy, Emilie
dc.contributor.authorIavicoli, Ivo
dc.contributor.authorJanasik, Beata
dc.contributor.authorJones, Kate
dc.contributor.authorLeese, Elizabeth
dc.contributor.authorLeso, Veruscka
dc.contributor.authorLouro, Henriqueta
dc.contributor.authorMajery, Nicole
dc.contributor.authorNdaw, Sophie
dc.contributor.authorPinhal, Hermínia
dc.contributor.authorRuggieri, Flavia
dc.contributor.authorSilva, Maria J.
dc.contributor.authorvan Nieuwenhuyse, An
dc.contributor.authorVerdonck, Jelle
dc.contributor.authorViegas, Susana
dc.contributor.authorWasowicz, Wojciech
dc.contributor.authorSepai, Ovnair
dc.contributor.authorScheepers, Paul T.J.
dc.contributor.authorAimonen, Kukka
dc.contributor.authorAntoine, Guillaume
dc.contributor.authorAnzion, Rob
dc.contributor.authorBurgart, Manuella
dc.contributor.authorCastaño, Argelia
dc.contributor.authorCattaneo, Andrea
dc.contributor.authorCavallo, Domenico Maria
dc.contributor.authorDe Palma, Giuseppe
dc.contributor.authorDenis, Flavien
dc.contributor.authorGambelunghe, Angela
dc.contributor.authorGomes, Bruno
dc.contributor.authorHanser, Ogier
dc.contributor.authorHelenius, Riikka
dc.contributor.authorLadeira, Carina
dc.contributor.authorLópez, Marta Esteban
dc.contributor.authorLovreglio, Piero
dc.contributor.authorMarsan, Philippe
dc.contributor.authorMelczer, Mathieu
dc.contributor.authorNogueira, Ana
dc.contributor.authorPletea, Elisabeta
dc.contributor.authorPoels, Katrien
dc.contributor.authorRemes, Jouko
dc.contributor.authorRibeiro, Edna
dc.contributor.authorSantos, Sílvia Reis
dc.contributor.authorSchaefers, Françoise
dc.contributor.authorSpankie, Sally
dc.contributor.authorSpoek, Robert
dc.contributor.authorRizki, Mohamed
dc.contributor.authorRousset, Davy
dc.contributor.authorvan Dael, Maurice
dc.contributor.authorVeijalainen, Henna
dc.date.accessioned2021-10-12T11:55:53Z
dc.date.available2021-10-12T11:55:53Z
dc.date.issued2022-03
dc.description.abstractExposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating, and other surface treatment processes. The aim of this study was to provide EU-relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint, and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding, the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSantonen T, Porras SP, Bocca B, Bousoumah R, Duca RC, Viegas S, et al. HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium. Environ Res. 2022;204(Part A):111984.pt_PT
dc.identifier.doi10.1016/j.envres.2021.111984pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13871
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S0013935121012792?via%3Dihubpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectHexavalent chromiumpt_PT
dc.subjectBiomonitoringpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectElectroplatingpt_PT
dc.subjectWeldingpt_PT
dc.titleHBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromiumpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issuePart Apt_PT
oaire.citation.startPage111984pt_PT
oaire.citation.titleEnvironmental Researchpt_PT
oaire.citation.volume204pt_PT
person.familyNameViegas
person.familyNameLadeira
person.givenNameSusana
person.givenNameCarina
person.identifier248817
person.identifier144237
person.identifier.ciencia-idA919-7318-63DC
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridI-4053-2012
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id36463788000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication13115332-43f7-4048-a8a5-2f2b855a8c92
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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