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Formalin-free histological fixation and its impact on organs, cells, proteins and nucleic acids: a systematic literature review

2024-03Conference object Open access
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dc.contributor.authorLino, Inês
dc.contributor.authorCarneiro, Joana
dc.contributor.authorViegas, Sara
dc.contributor.authorBorges-Ferro, Amadeu
dc.date.accessioned2024-04-04T11:57:06Z
dc.date.available2024-04-04T11:57:06Z
dc.date.issued2024-03
dc.description.abstractTo preserve biological tissues and their components against natural degradation, a fixation step must be used providing it with the necessary robustness to withstand further processing. 10% neutral buffered formalin (NBF) is the most widely used fixative, however, this is highly toxic and carcinogenic, posing a risk to the health of professionals and the environment. This review arises from the need to find a less harmful alternative to formalin that could lead to the reduction/elimination of exposure to this reagent. To research the possibility of eliminating the use of formalin, this review aims to compare the results obtained using formalin with alternative formalin-free compounds in biological targets (e.g., organs, cells, proteins, and nucleic acids).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLino I, Carneiro J, Viegas S, Borges-Ferro A. Formalin-free histological fixation and its impact on organs, cells, proteins and nucleic acids: a systematic literature review. In: II Congresso BioMedLab, Convento de S. Francisco (Coimbra), 1-3 de março de 2024.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17254
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAssociação Portuguesa de Ciências Biomédicas Laboratoriaispt_PT
dc.relation.publisherversionhttps://abiomedlab.org/abstract-book-do-ii-congresso-da-biomedlab/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectFixationpt_PT
dc.subjectAlternative fixativespt_PT
dc.subjectFormalinpt_PT
dc.titleFormalin-free histological fixation and its impact on organs, cells, proteins and nucleic acids: a systematic literature reviewpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceCoimbrapt_PT
person.familyNameBORGES FERRO
person.givenNameAMADEU JOSÉ
person.identifier.ciencia-idFA16-8351-EB4A
person.identifier.orcid0000-0002-3450-5758
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationf823b4bf-d2e4-456e-a7fa-b35180ff403f
relation.isAuthorOfPublication.latestForDiscoveryf823b4bf-d2e4-456e-a7fa-b35180ff403f

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