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Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial

2023-06Artigo científico Acesso aberto
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dc.contributor.authorWood, Eleanor
dc.contributor.authorHein, Sabine
dc.contributor.authorMesnage, Robin
dc.contributor.authorFernandes, Filipe
dc.contributor.authorAbhayaratne, Nimaya
dc.contributor.authorXu, Yifan
dc.contributor.authorZhang, Zicheng
dc.contributor.authorBell, Lynne
dc.contributor.authorWilliams, Claire
dc.contributor.authorRodriguez-Mateos, Ana
dc.date.accessioned2023-04-26T12:23:03Z
dc.date.embargo2025-04-26
dc.date.issued2023-06
dc.description.abstractBackground: Evidence suggests that the intake of blueberry (poly)phenols is associated with improvements in vascular function and cognitive performance. Whether these cognitive effects are linked to increases in cerebral and vascular blood flow or changes in the gut microbiota is currently unknown. Methods: A double-blind, parallel randomized controlled trial was conducted in 61 healthy older individuals aged 65-80 y. Participants received either 26 g of freeze-dried wild blueberry (WBB) powder (302 mg anthocyanins) or a matched placebo (0 mg anthocyanins). Endothelial function measured by flow-mediated dilation (FMD), cognitive function, arterial stiffness, blood pressure (BP), cerebral blood flow (CBF), gut microbiome, and blood parameters were measured at baseline and 12 wk following daily consumption. Plasma and urinary (poly)phenol metabolites were analyzed using microelution solid-phase extraction coupled with liquid chromatography-mass spectrometry. Results: A significant increase in FMD and reduction in 24 h ambulatory systolic BP were found in the WBB group compared with the placebo group (0.86%; 95% CI: 0.56, 1.17, P < 0.001; -3.59 mmHg; 95% CI: -6.95, -0.23, P = 0.037; respectively). Enhanced immediate recall on the auditory verbal learning task, alongside better accuracy on a task-switch task, was also found following WBB treatment compared with placebo (P < 0.05). Total 24 h urinary (poly)phenol excretion increased significantly in the WBB group compared with placebo. No changes in the CBF or gut microbiota composition were found. Conclusions: Daily intake of WBB powder, equivalent to 178 g fresh weight, improves vascular and cognitive function and decreases 24 h ambulatory systolic BP in healthy older individuals. This suggests that WBB (poly)phenols may reduce future CVD risk in an older population and may improve episodic memory processes and executive functioning in older adults at risk for cognitive decline. Clinical Trial Registration number in clinicaltrials.gov: NCT04084457.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationWood E, Hein S, Mesnage R, Fernandes F, Abhayaratne N, Xu Y, et al. Wild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trial. Am J Clin Nutr. 2023;117(6):1306-19.pt_PT
dc.identifier.doi10.1016/j.ajcnut.2023.03.017pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15942
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/abs/pii/S0002916523463009pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCerebral blood flowpt_PT
dc.subjectCognitionpt_PT
dc.subjectFlow-mediated dilationpt_PT
dc.subjectGut microbiotapt_PT
dc.subjectMetabolomicspt_PT
dc.subjectNutritionpt_PT
dc.subjectOlder adultspt_PT
dc.subjectPolyphenolpt_PT
dc.subjectVascular functionpt_PT
dc.subjectWild blueberrypt_PT
dc.titleWild blueberry (poly)phenols can improve vascular function and cognitive performance in healthy older individuals: a double-blind randomized controlled trialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1319pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1306pt_PT
oaire.citation.titleThe American Journal of Clinical Nutritionpt_PT
oaire.citation.volume117pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT

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