Role of DNA methylation in persistent diabetic macular edema

Background: a) Disease duration and metabolic control are insufficient to understand Diabetic Macular Edema (DME), the leading cause of vision loss in people with diabetes; b) 30-40% of cases of DME do not respond optimally to AVEGF (loading phase); c) poor genetic association in DR development (<25% RD) and PDR progression (25-50%). Purpose: To study the role of DNA methyltransferase expression (DNMT1,DNMT3a, DNMT3b) in persistent diabetic macular edema.

Description

Projeto ID&CA 2021_IPL/2021/DiffMeDiME_ESTeSL

Keywords

Ophthalmology Persistent diabetic macular edema DNA methylation IPL/2021/DiffMeDiME_ESTeSL

URI

http://hdl.handle.net/10400.21/16420

Citation

Camacho P, Pereira B, Ribeiro E, Silva C, Delgadinho M, Oliveira K, Brito M, et al. Role of DNA methylation in persistent diabetic macular edema. In: 40th Congress of the ESCRS, Milan (Italy), September 16-20, 2022.