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Sickle cell disease: current drug treatments and functional foods with therapeutic potential

2024-06Journal article Open access
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dc.contributor.authorGonçalves, Elisângela
dc.contributor.authorSmaoui, Slim
dc.contributor.authorBrito, Miguel
dc.contributor.authorOliveira, J. M.
dc.contributor.authorArez, Ana Paula
dc.contributor.authorTavares, Loleny
dc.date.accessioned2024-07-29T09:56:35Z
dc.date.available2024-07-29T09:56:35Z
dc.date.issued2024-06
dc.descriptionMiguel Brito gratefully acknowledges the FCT/MCTES national support through the projects H&TRC UIDB/05608/2020, UIDP/05608/2020, and IPL/IDI&CA2023/Ipasthma_ESTeSL. J.M. Oliveira acknowledges the financial support of CICECO–Aveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020, financed by national funds through the FCT/MCTES (PIDDAC). Ana Paula Arez would like to acknowledge Fundação para a Ciência e a Tecnologia for funds to GHTM—UID/04413/2020 and LA-REAL LA/P/0117/2020.pt_PT
dc.description.abstractSickle cell anemia (SCA), the most common form of sickle cell disease (SCD), is a genetic blood disorder. Red blood cells break down prematurely, causing anemia and often blocking blood vessels, leading to chronic pain, organ damage, and increased infection risk. SCD arises from a single-nucleotide mutation in the β-globin gene, substituting glutamic acid with valine in the β-globin chain. This review examines treatments evaluated through randomized controlled trials for managing SCD, analyzes the potential of functional foods (dietary components with health benefits) as a complementary strategy, and explores the use of bioactive compounds as functional food ingredients. While randomized trials show promise for certain drugs, functional foods enriched with bioactive compounds also hold therapeutic potential. Further research is needed to confirm clinical efficacy, optimal dosages, and specific effects of these compounds on SCD, potentially offering a cost-effective and accessible approach to managing the disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGonçalves E, Smaoui S, Brito M, Oliveira JM, Arez AP, Tavares L. Sickle cell disease: current drug treatments and functional foods with therapeutic potential. Curr Issues Mol Biol. 2024;46(6):5845-65.pt_PT
dc.identifier.doi10.3390/cimb46060349pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17598
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationIPL/IDI&CA2023/Ipasthma_ESTeSLpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/1467-3045/46/6/349pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectSickle cell diseasept_PT
dc.subjectSickle cell anemiapt_PT
dc.subjectBioactive compoundspt_PT
dc.subjectClinical trialspt_PT
dc.subjectFunctional foodpt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.subjectIPL/IDI&CA2023/Ipasthma_ESTeSLpt_PT
dc.titleSickle cell disease: current drug treatments and functional foods with therapeutic potentialpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage5865pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage5845pt_PT
oaire.citation.titleCurrent Issues in Molecular Biologypt_PT
oaire.citation.volume46pt_PT
person.familyNameBrito
person.givenNameMiguel
person.identifier.ciencia-id231F-F341-7E93
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication4252d8e0-800c-4d67-8b13-0b711d860669
relation.isAuthorOfPublication.latestForDiscovery4252d8e0-800c-4d67-8b13-0b711d860669

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