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Thiadiazolidinone-8 ameliorates inflammation associated with experimental colitis in mice

2018-01Journal article Restricted access
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dc.contributor.authorMateus, Vanessa
dc.contributor.authorRocha, João
dc.contributor.authorAlves, Paula
dc.contributor.authorMota-Filipe, Hélder
dc.contributor.authorSepodes, Bruno
dc.contributor.authorPinto, Rui
dc.date.accessioned2018-01-11T16:32:39Z
dc.date.available2018-01-11T16:32:39Z
dc.date.issued2018-01
dc.description.abstractThiadiazolidinone-8 (TDZD-8) is an effective thiadiazolidinone derivate that is able to suppress the expression of inflammatory cytokines; it also presents tissue protective actions by glycogen synthase kinase (GSK)-3β inhibition, promoting thus an anti-inflammatory effect. Since inflammatory bowel disease is a chronic disease with reduced quality of life, where currently available therapies are only able to induce or maintain the patient in remission, it is crucial to investigate new pharmacological approaches. The main objective of this study was to evaluate the effect of TDZD-8 in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. Male CD-1 mice with TNBS-induced colitis were treated with a daily dose of TDZD-8 5 mg/kg/day IP for 4 days. The anti-inflammatory properties of TDZD-8 in the TNBS-induced colitis were confirmed by suppression of pro-inflammatory mediators, such as tumor necrosis factor (TNF)-α, interleukin (IL)-1β and myeloperoxidase, as well as by the significant increase of the anti-inflammatory cytokine, IL-10. These treated mice also presented a reduction in fecal hemoglobin and alkaline phosphatase, suggesting a beneficial effect of TDZD-8. Furthermore, renal and hepatic biomarkers remained stabilized after treatment. In conclusion, TDZD-8 reduces the inflammatory response associated with TNBS-induced colitis in mice, and modulation of GSK-3β seems to be an interesting pharmacological target in colitis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMateus V, Rocha J, Alves P, Mota-Filipe H, Sepodes B, Pinto R. Thiadiazolidinone-8 ameliorates inflammation associated with experimental colitis in mice. Pharmacology. 2018;101(1-2):35-42.pt_PT
dc.identifier.doi10.1159/000471808pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/7898
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherKarger Publisherspt_PT
dc.relation.publisherversionhttps://www.karger.com/Article/Abstract/471808pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectExperimental colitispt_PT
dc.subjectTrinitrobenzene sulfonic acid-induced colitispt_PT
dc.subjectInflammationpt_PT
dc.subjectThiadiazolidinone-8pt_PT
dc.subjectGlycogen synthase kinase-3β inhibitorpt_PT
dc.titleThiadiazolidinone-8 ameliorates inflammation associated with experimental colitis in micept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage42pt_PT
oaire.citation.issue1-2pt_PT
oaire.citation.startPage35pt_PT
oaire.citation.titlePharmacologypt_PT
oaire.citation.volume101pt_PT
person.familyNamePinho Mateus
person.givenNameVanessa Alexandra
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.orcid0000-0002-3204-3772
rcaap.rightsrestrictedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublication.latestForDiscovery406041a5-682c-4f94-a4e2-ddbfc541313c

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