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Epidemiological, social and economic burden of severe hypoglycaemia in patients with diabetes mellitus in Portugal: a structured literature review

2023-02Journal article Open access
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dc.contributor.authorSoares, Ana Rita
dc.contributor.authorCoelho, Marisa
dc.contributor.authorTracey, Marsha
dc.contributor.authorCarvalho, Davide
dc.contributor.authorSilva-Nunes, José
dc.date.accessioned2023-02-03T16:47:42Z
dc.date.available2023-02-03T16:47:42Z
dc.date.issued2023-02
dc.description.abstractIntroduction: The aim of this review was to identify and review studies reporting on the epidemiological, social, and economic impact associated with severe hypoglycemia (SH) in people with diabetes mellitus (DM) in Portugal. Methods: A structured literature search was carried out in PubMed and Embase using a predefined selection criterion. Studies published in either Portuguese or English, between January 2010 and February 2021 were deemed eligible for inclusion. Results: Twelve studies including adults (aged ≥ 18 years) with type 1 and/or type 2 diabetes mellitus (T1DM/T2DM) were eligible for inclusion. Epidemiological estimates varied according to the setting and type of data source used. The proportion of patients who experienced ≥ 1 SH episode (SHE) in the previous 6-12 months varied from 3.1% in adults with T2DM to 36.8% in adults with T1DM. In adults with T2DM, the prevalence in a community-based study was highest in the insulin and secretagogue combination-treated group (9.1%), while in an emergency department setting prevalence was highest in the insulin-based therapy group and the oral hypoglycaemic agent without secretagogues group (32.0% and 20.0%, respectively). The prevalence of SH in other studies of patients with DM ranged from 0.1% (emergency department) to 18.1% (hospital ward). Patients treated with secretagogues had the highest rates of hospitalizations. In patients with T1DM, the annual rate of SHE was higher in those with impaired hypoglycemia awareness than in those with intact awareness. Mean total cost (direct and indirect) per SHE ranged from €1493.00 in patients with T2DM treated in an emergency setting to €2608.51 in patients with T1DM who were hospitalized. Conclusion: Hypoglycaemic events, especially SHE, have a significant effect on the life of persons living with DM and their caregivers. Studies show that the prevalence of this acute complication of diabetes is not negligible. In addition to the negative impact on the quality of life, the burden of SHE in Portugal translates into a significant impact on global health expenditure.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSoares AR, Coelho M, Tracey M, Carvalho D, Silva-Nunes J. Epidemiological, social and economic burden of severe hypoglycaemia in patients with diabetes mellitus in Portugal: a structured literature review. Diabetes Ther. 2023;14(2):265-91.pt_PT
dc.identifier.doi10.1007/s13300-022-01358-1pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15485
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s13300-022-01358-1pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectDiabetes mellituspt_PT
dc.subjectAcute diabetes complicationspt_PT
dc.subjectIllness costspt_PT
dc.subjectDiabetes complications burdenpt_PT
dc.subjectEpidemiologypt_PT
dc.subjectSevere hypoglycemiapt_PT
dc.subjectPortugalpt_PT
dc.subjectStructured literature reviewpt_PT
dc.titleEpidemiological, social and economic burden of severe hypoglycaemia in patients with diabetes mellitus in Portugal: a structured literature reviewpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage291pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage265pt_PT
oaire.citation.titleDiabetes Therapypt_PT
oaire.citation.volume14pt_PT
person.familyNameSilva-Nunes
person.givenNameJosé António
person.identifier.ciencia-id4B1C-E132-25F0
person.identifier.orcid0000-0002-4728-1220
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9352b380-9661-4316-ab88-6ed9be1020ac
relation.isAuthorOfPublication.latestForDiscovery9352b380-9661-4316-ab88-6ed9be1020ac

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