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Serum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feeding

2016-06Journal article Restricted access
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dc.contributor.authorSantos, Carla Adriana
dc.contributor.authorFonseca, Jorge
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorSousa Guerreiro, António
dc.date.accessioned2015-09-04T15:57:11Z
dc.date.available2015-09-04T15:57:11Z
dc.date.issued2016-06
dc.description.abstractBackground & aims - Patients who underwent endoscopic gastrostomy (PEG) present protein-energy malnutrition, but little is known about Trace Elements (TE), Zinc (Zn), Copper (Cu), Selenium (Se), Iron (Fe), Chromium (Cr). Our aim was the evaluation of serum TE in patients who underwent PEG and its relationship with serum proteins, BMI and nature of underlying disorder. Methods - A prospective observational study was performed collecting: patient's age, gender, underlying disorder, NRS-2002, BMI, serum albumin, transferrin and TE concentration. We used ferrozine colorimetric method for Fe; Inductively Coupled Plasma-Atomic Emission Spectroscopy for Zn/Cu; Furnace Atomic Absorption Spectroscopy for Se/Cr. The patients were divided into head and neck cancer (HNC) and neurological dysphagia (ND). Results - 146 patients (89 males), 21–95 years: HNC-56; ND-90. Low BMI in 78. Low values mostly for Zn (n = 122) and Fe (n = 69), but less for Se (n = 31), Cu (n = 16), Cr (n = 7); low albumin in 77, low transferrin in 94 and 66 with both proteins low. Significant differences between the groups of underlying disease only for Zn (t140.326 = −2,642, p < 0.01) and a correlation between proteins and TE respectively albumin and Zn (r = 0.197, p = 0.025), and albumin and Fe (r = 0.415, p = 0.000). Conclusions - When gastrostomy was performed, patients display low serum TE namely Zn, but also Fe, less striking regarding others TE. It was related with prolonged fasting, whatever the underlying disease. Low proteins were associated with low TE. Teams taking care of PEG-patients should use Zn supplementation and include other TE evaluation as part of the nutritional assessment of PEG candidates.por
dc.identifier.citationSantos CA, Fonseca J, Carolino E, Guerreiro AS. Serum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feeding. Clin Nutr. 2016;35(3):718-23.por
dc.identifier.doi10.1016/j.clnu.2015.05.006
dc.identifier.urihttp://hdl.handle.net/10400.21/5056
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0261561415001387por
dc.subjectDysphagiapor
dc.subjectGastrostomypor
dc.subjectNutritionpor
dc.subjectPEGpor
dc.subjectTrace elementspor
dc.subjectEnteral feedingpor
dc.titleSerum trace elements in dysphagic gastrostomy candidates before endoscopic gastrostomy for long term enteral feedingpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleClinical Nutritionpor
person.familyNameCarolino
person.givenNameElisabete
person.identifier.ciencia-id1216-EFA3-1E0F
person.identifier.orcid0000-0003-4165-7052
person.identifier.ridF-1012-2015
person.identifier.scopus-author-id25821697000
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor
relation.isAuthorOfPublication77930d39-ed34-44dc-a4a6-9bf833e5e688
relation.isAuthorOfPublication.latestForDiscovery77930d39-ed34-44dc-a4a6-9bf833e5e688

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