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Publication
Projeto de um sistema AVAC para uma unidade farmacêutica de enchimento assético de injetáveis
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 31.43 MB | Adobe PDF |
Advisor(s)
Abstract(s)
O fabrico e manuseio de produtos farmacêuticos requerem salas limpas, onde o controlo rigoroso de contaminantes e microorganismos é essencial. A qualidade do ar interior é crucial para garantir a segurança do produto, dos trabalhadores e do meio ambiente. Parâmetros como temperatura, humidade relativa, partículas no ar, fluxo de ar, pressão interior e cargas internas devem ser cuidadosamente monitorizados para evitar contaminações. Com o presente trabalho, pretende-se desenvolver a componente aeráulica de um sistema de AVAC para um conjunto de salas limpas de classe C e D. Para a elaboração do projeto e para alcançar a solução proposta, foi fundamental considerar a legislação vigente e realizar cálculos essenciais, como as necessidades de ar novo e extração, o dimensionamento aeráulico (utilizando os métodos de redução de velocidade para insuflação e perda de carga constante para extração), além dos cálculos de potências de arrefecimento e aquecimento necessários. Também foram consideradas as perdas de carga nos circuitos aeráulicos. O dimensionamento dos sistemas e equipamentos, assim como as cargas térmicas do edifício, foi apoiado pelo software Carrier – HAP (Hourly Analysis Program). Conhecendo as potências necessárias a vencer, 73,4 kW no caso do arrefecimento e 66,5 kW no aquecimento, partiu-se para a seleção da solução, optando-se por duas Unidades de Tratamento de Ar (UTA) com apoio de difusores de insuflação, como unidades terminais. A escolha de utilizar duas UTA deve-se à necessidade de distribuir de forma equilibrada as elevadas cargas térmicas, permitindo um controlo mais eficaz da temperatura nas diferentes zonas do ambiente. Esta abordagem garante maior flexibilidade, redundância e eficiência no desempenho do sistema, além de assegurar que as variáveis térmicas sejam atendidas de maneira otimizada. A implementação do sistema projetado visa então garantir a conformidade com os padrões da indústria farmacêutica, proporcionando um ambiente seguro e controlado, essencial para a produção de medicamentos de alta qualidade.
Abstract The manufacturing and handling of pharmaceutical products require cleanrooms, where strict control of contaminants and microorganisms is essential. The quality of the indoor air is crucial to ensure the safety of the product, the workers, and the environment. Parameters such as temperature, relative humidity, airborne particles, air flow, internal pressure, and internal loads must be carefully monitored to prevent contamination. The aim of this work is to develop the air handling component of an HVAC system for a set of cleanrooms classified as Class C and D. For the design of the project and to achieve the proposed solution it was essential to consider the current legislation and perform key calculations, such as the requirements for fresh air and extraction, the air system design (using the methods of velocity reduction for supply air and constant pressure loss for extraction), as well as the calculations for the required cooling and heating capacities. Pressure losses in the air circuits were also taken into account. The system and equipment design, along with the thermal loads of the building, was supported by the Carrier – HAP (Hourly Analysis Program) software. Knowing the necessary powers to overcome,73,4 kW for cooling and 66,5 kW for heating, the solution selection proceeded, opting for two air handling units (AHUs) with supply air diffusers as terminal units. The choice to use two AHUs is due to the need to distribute the high thermal loads evenly, allowing for more effective temperature control in different areas of the environment. This approach ensures greater flexibility, redundancy, and efficiency in the system's performance, while ensuring that the thermal variables are optimally met. The implementation of the designed system aims to ensure compliance with pharmaceutical industry standards, providing a safe and controlled environment, essential for the production of high-quality medicines.
Abstract The manufacturing and handling of pharmaceutical products require cleanrooms, where strict control of contaminants and microorganisms is essential. The quality of the indoor air is crucial to ensure the safety of the product, the workers, and the environment. Parameters such as temperature, relative humidity, airborne particles, air flow, internal pressure, and internal loads must be carefully monitored to prevent contamination. The aim of this work is to develop the air handling component of an HVAC system for a set of cleanrooms classified as Class C and D. For the design of the project and to achieve the proposed solution it was essential to consider the current legislation and perform key calculations, such as the requirements for fresh air and extraction, the air system design (using the methods of velocity reduction for supply air and constant pressure loss for extraction), as well as the calculations for the required cooling and heating capacities. Pressure losses in the air circuits were also taken into account. The system and equipment design, along with the thermal loads of the building, was supported by the Carrier – HAP (Hourly Analysis Program) software. Knowing the necessary powers to overcome,73,4 kW for cooling and 66,5 kW for heating, the solution selection proceeded, opting for two air handling units (AHUs) with supply air diffusers as terminal units. The choice to use two AHUs is due to the need to distribute the high thermal loads evenly, allowing for more effective temperature control in different areas of the environment. This approach ensures greater flexibility, redundancy, and efficiency in the system's performance, while ensuring that the thermal variables are optimally met. The implementation of the designed system aims to ensure compliance with pharmaceutical industry standards, providing a safe and controlled environment, essential for the production of high-quality medicines.
Description
Trabalho de projeto para obtenção do grau de Mestre em Engenharia Mecânica, na Área de Especialização de Energia, Climatização e Refrigeração
Keywords
Sistemas AVAC Indústria farmacêutica Salas limpas Qualidade do ar interior Normalização HVAC systems Pharmaceutical industry Cleanrooms Indoor air quality Standardization
Citation
FERNANDES, Margarida Isabel Gonçalves Assis – Projeto de um sistema AVAC para uma unidade farmacêutica de enchimento assético de injetáveis. Lisboa: Instituto Superior de Engenharia de Lisboa. 2024. Dissertação de Mestrado.