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Classification and staging of chronic liver disease from multimodal data

dc.contributor.authorRibeiro, Ricardo
dc.contributor.authorMarinho, Rui
dc.contributor.authorSanches, João
dc.date.accessioned2013-12-16T17:38:34Z
dc.date.available2013-12-16T17:38:34Z
dc.date.issued2013-05
dc.description.abstractChronic liver disease (CLD) is most of the time an asymptomatic, progressive, and ultimately potentially fatal disease. In this study, an automatic hierarchical procedure to stage CLD using ultrasound images, laboratory tests, and clinical records are described. The first stage of the proposed method, called clinical based classifier (CBC), discriminates healthy from pathologic conditions. When nonhealthy conditions are detected, the method refines the results in three exclusive pathologies in a hierarchical basis: 1) chronic hepatitis; 2) compensated cirrhosis; and 3) decompensated cirrhosis. The features used as well as the classifiers (Bayes, Parzen, support vector machine, and k-nearest neighbor) are optimally selected for each stage. A large multimodal feature database was specifically built for this study containing 30 chronic hepatitis cases, 34 compensated cirrhosis cases, and 36 decompensated cirrhosis cases, all validated after histopathologic analysis by liver biopsy. The CBC classification scheme outperformed the nonhierachical one against all scheme, achieving an overall accuracy of 98.67% for the normal detector, 87.45% for the chronic hepatitis detector, and 95.71% for the cirrhosis detector.por
dc.identifier.citationRibeiro R, Marinho R, Sanches J. Classification and staging of chronic liver disease from multimodal data. IEEE Trans Biomed Eng. 2013;60(5):1336-44.por
dc.identifier.issn1558-2531
dc.identifier.urihttp://hdl.handle.net/10400.21/3010
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherIEEEpor
dc.relation.publisherversionhttp://ieeexplore.ieee.org/xpl/articleDetails.jsp?arnumber=6387584por
dc.subjectChronic liver diseasepor
dc.subjectCirrhosispor
dc.subjectClassificationpor
dc.subjectUltrasound-based textural featurespor
dc.subjectBiopsypor
dc.subjectFeature extractionpor
dc.subjectLaboratoriespor
dc.subjectLiverpor
dc.subjectMedical diagnostic imagingpor
dc.subjectSupport vector machinespor
dc.titleClassification and staging of chronic liver disease from multimodal datapor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1344por
oaire.citation.startPage1336por
oaire.citation.titleIEEE transactions on bio-medical engineeringpor
oaire.citation.volume60por
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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