Vagus nerve stimulation for the management of immune-mediated inflammatory diseases

Tarn, Jessica; Pinto, Ines Figueiredo; Ng, Wan-Fai

http://hdl.handle.net/10400.21/21626

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Authors

Tarn, Jessica

Pinto, Ines Figueiredo

Ng, Wan-Fai

Abstract(s)

The vagus nerve is a key component of several homeostatic axes including the cholinergic antiinflammatory pathway, hypothalamic–pituitary-adrenergic axis, and the brain-gut axis, all of which play important roles in the regulation of the immune system. Autonomic dysfunction has been described in many immune-mediated inflammatory diseases (IMIDs). In addition, several pilot studies have shown that vagus nerve stimulation leads to improvement in several IMIDs. Taken together, the vagus nerve is a promising novel therapeutic target for the management of IMIDs.

Keywords

Immunemediated inflammatory diseases Vagus nerve Autonomic nervous system Cholinergic antiinflammatory Hypothalamic–pituitary-adrenal Brain-gut Inflammatory bowel disease Primary Sjogren’s syndrome Scleroderma Systemic lupus erythematosus

URI

http://hdl.handle.net/10400.21/21626

Citation

Tarn J, Pinto IF, Ng WF. Vagus nerve stimulation for the management of immune-mediated inflammatory diseases. In: Staats PS, Ayata C, Abd-Elsayed A, editors. Vagus nerve stimulation. Academic Press; 2025. p. 275-86.