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Evaluating the levels of endotoxins in health care facilities

2019-09Conference object Open access
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dc.contributor.authorPereira, C.
dc.contributor.authorAlmeida, Beatriz
dc.contributor.authorLage, B.
dc.contributor.authorMarrafaia, M.
dc.contributor.authorPaciência, I.
dc.contributor.authorRufo, J. Cavaleiro
dc.contributor.authorTeixeira, João Paulo
dc.contributor.authorViegas, Carla
dc.date.accessioned2019-11-28T13:36:53Z
dc.date.available2019-11-28T13:36:53Z
dc.date.issued2019-09
dc.descriptionProject EXPOsE. Project nº 23222 (02/SAICT/2016).pt_PT
dc.description.abstractEndotoxins are biologically active lipopolysaccharides (LPSs) produced by the most external layer of cell walls of Gram-negative bacteria and are present ubiquitously in the environment. Endotoxin levels are related to the occurrence of Gram-negative bacteria and acute health effects like dry cough and shortness of breath, decrease in lung function, fever reaction and malaise, dyspnea and headaches have been described as occurring upon endotoxin exposure as well as chronic health effects caused by the inflammatory response within the airways. Although many studies have already associated endotoxin exposure, especially in workplaces, to airways disease, a threshold limit value for occupational exposure has not been set yet, and the only available reference is from the Dutch Expert Committee on Occupational Safety (DECOS) that recommends a health-based occupational exposure limit (HBROEL) for endotoxin of 90 EU /m3 over an 8-hour period. Nevertheless, this limit has been subjected to some criticism as it was established based on human volunteer exposure challenge studies and not workplace studies, and therefore, may understate the adverse effect of lowest concentrations of endotoxin. Environmental monitoring is usually performed by sampling airborne dust and subsequent analysis by the Limulus Amebocyte Lysate (LAL) assay. This study aims to assess the levels of endotoxins present in different areas of a Central Hospital in Porto, Portugal, to determine the occupational exposure risk, as well as to compare two sampling methods: sampling on glass fiber filters with air pump following the European Standard (2003) EN 14031 and sampling by vacuumed dust. Fifteen air samples and 5 dust samples were obtained.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPereira C, Almeida B, Lage B, Marrafaia M, Paciência I, Viegas C, et al. Evaluating the levels of endotoxins in health care facilities. In: ICEH 2019 – International Congress on Environmental Health, ESTeSL, Lisbon (Portugal), September 25-27, 2019.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/10765
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relationProject EXPOsEpt_PT
dc.relationProject nº 23222 (02/SAICT/2016)pt_PT
dc.relation.publisherversionhttps://iceh2019.estesl.ipl.pt/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectHealthcare professionalpt_PT
dc.subjectHealthcare facilitiespt_PT
dc.subjectEndotoxinspt_PT
dc.subjectHospitalpt_PT
dc.subjectPortugalpt_PT
dc.subjectPortopt_PT
dc.subjectProject EXPOsEpt_PT
dc.subjectProject nº 23222 (02/SAICT/2016)pt_PT
dc.titleEvaluating the levels of endotoxins in health care facilitiespt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceLisboapt_PT
person.familyNameViegas
person.givenNameCarla
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.orcid0000-0002-1545-6479
person.identifier.ridB-7217-2013
person.identifier.scopus-author-id55443609700
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublicationb5fa5da4-50c3-4b88-ae20-1bc63cb485f7
relation.isAuthorOfPublication.latestForDiscoveryb5fa5da4-50c3-4b88-ae20-1bc63cb485f7

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