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Antibody production for diagnostic applications and therapeutic development: is it possible to reduce the use of animals?

2025-03Póster em conferência Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorSushchenko, Yelyzaveta
dc.contributor.authorTuriel, Ema
dc.contributor.authorAguiar, Joana
dc.contributor.authorJaneiro, Mariana
dc.contributor.authorBorges-Ferro, A
dc.date.accessioned2025-12-23T09:17:36Z
dc.date.available2025-12-23T09:17:36Z
dc.date.issued2025-03
dc.description.abstractTraditionally, antibodies have been produced using the hybridoma technique, which involves immunization and the sacrifice of animals. Although this has revolutionized the practice of “traditional” immunohistochemistry, it currently raises some ethical questions regarding animal suffering. Therefore, it is important to develop methods that are viable to obtain quality antibodies for human diagnosis and therapy, while also having a less significant impact on animal welfare. There are several promising methods, such as the use of mammalian cells, the expression of antibodies in phage display, and even in yeasts. This review aims to explore alternative methods for antibody production, highlighting their advantages and limitations.eng
dc.identifier.citationSushchenko Y, Turiel E, Aguiar J, Janeiro M, Borges-Ferro A. Antibody production for diagnostic applications and therapeutic development: is it possible to reduce the use of animals? In: III Congresso Nacional da BioMedLab, Auditório Prof. Armando Simões dos Santos, Faculdade de Medicina Dentária, Universidade de Lisboa, 7 a 9 de março de 2025.
dc.identifier.urihttp://hdl.handle.net/10400.21/22400
dc.language.isoeng
dc.peerreviewedyes
dc.relation.hasversionhttps://biomedlab.pt/3-congresso/
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectDiagnostic applications
dc.subjectTherapeutic development
dc.subjectImmunohistochemistry
dc.subjectAnimal suffering
dc.subjectSystematic review
dc.titleAntibody production for diagnostic applications and therapeutic development: is it possible to reduce the use of animals?eng
dc.typeconference poster
dspace.entity.typePublication
oaire.citation.conferenceDate2025-03
oaire.citation.conferencePlaceLisboa, Portugal
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameBORGES FERRO
person.givenNameAMADEU JOSÉ
person.identifier.ciencia-idFA16-8351-EB4A
person.identifier.orcid0000-0002-3450-5758
relation.isAuthorOfPublicationf823b4bf-d2e4-456e-a7fa-b35180ff403f
relation.isAuthorOfPublication.latestForDiscoveryf823b4bf-d2e4-456e-a7fa-b35180ff403f

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