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TBCCD1 is a key regulator of centrosomal microtubule anchor and basal body positioning/attachment

2018-10Documento de conferência Acesso aberto
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dc.contributor.authorCarmona, Bruno
dc.contributor.authorCamelo, Carolina
dc.contributor.authorMehraz, Manon
dc.contributor.authorLemullois, Michel
dc.contributor.authorNolasco, Sofia
dc.contributor.authorMarinho, H. Susana
dc.contributor.authorTassin, Anne-Marie
dc.contributor.authorKoll, France
dc.contributor.authorSoares, Helena
dc.date.accessioned2019-05-16T15:18:04Z
dc.date.available2019-05-16T15:18:04Z
dc.date.issued2018-10
dc.description.abstractSuccessful cilia assembly requires correct positioning and anchoring of the centrosome's mother centriole/basal body (BB) to the cell membrane. A clear picture of the different signals and players involved in centrosome positioning/anchoring is still not available. Published work from our group identified a new TBCC domain-containing human protein (TBCCD1). Depletion of TBCCD1 in human RPE-1 cells severely affects the relative position of the centrosome to the nucleus and the efficiency of cells to assemble primary cilia. Aim of the study: To dissect the mechanisms involving TBCCD1 in human RPE-1 positioning and anchoring during ciliogenesis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCarmona B, Camelo C, Mehraz M, Lemullois M, Nolasco S, Soares H, et al. TBCCD1 is a key regulator of centrosomal microtubule anchor and basal body positioning/attachment. In: EMBO Workshop Cilia 2018, Copenhagen (Denmark), October 2-5, 2018.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/10029
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttp://meetings.embo.org/event/18-ciliapt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCentrosomespt_PT
dc.subjectBasal bodypt_PT
dc.subjectCiliogenesispt_PT
dc.titleTBCCD1 is a key regulator of centrosomal microtubule anchor and basal body positioning/attachmentpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlaceCopenhagapt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT

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