TBCCD1 is a key regulator of centrosomal microtubule anchor and basal body positioning/attachment

Carmona, Bruno; Camelo, Carolina; Mehraz, Manon; Lemullois, Michel; Nolasco, Sofia; Marinho, H. Susana; Tassin, Anne-Marie; Koll, France; Soares, Helena

http://hdl.handle.net/10400.21/10029

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Abstract(s)

Successful cilia assembly requires correct positioning and anchoring of the centrosome's mother centriole/basal body (BB) to the cell membrane. A clear picture of the different signals and players involved in centrosome positioning/anchoring is still not available. Published work from our group identified a new TBCC domain-containing human protein (TBCCD1). Depletion of TBCCD1 in human RPE-1 cells severely affects the relative position of the centrosome to the nucleus and the efficiency of cells to assemble primary cilia. Aim of the study: To dissect the mechanisms involving TBCCD1 in human RPE-1 positioning and anchoring during ciliogenesis.

Keywords

Centrosomes Basal body Ciliogenesis

URI

http://hdl.handle.net/10400.21/10029

Citation

Carmona B, Camelo C, Mehraz M, Lemullois M, Nolasco S, Soares H, et al. TBCCD1 is a key regulator of centrosomal microtubule anchor and basal body positioning/attachment. In: EMBO Workshop Cilia 2018, Copenhagen (Denmark), October 2-5, 2018.