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Genotoxic assessment in different exposure groups working with antineoplastic agents

2015Journal article Unknown
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dc.contributor.authorLadeira, Carina
dc.contributor.authorViegas, Susana
dc.contributor.authorPádua, Mário
dc.contributor.authorCarolino, Elisabete
dc.contributor.authorGomes, Manuel C.
dc.contributor.authorBrito, Miguel
dc.date.accessioned2015-08-20T15:07:38Z
dc.date.available2015-08-20T15:07:38Z
dc.date.issued2015
dc.description.abstractAntioneoplastic drugs are widely used in treatment of cancer, and several studies suggest acute and long-term effects associated to antineoplastic drug exposures, namely associating workplace exposure with health effects. Cytokinesis blocked micronucleus (CBMN) assay is one promising short-term genotoxicity assays for human risk assessment and their combination is recommended to monitor populations chronically exposed to genotoxic agents. The aim of this investigation is the genotoxicity assessment in different professionals that handle cytostatics drugs. This research is case-control blinded study constituted by 46 non-exposed subjects and 44 workers that handle antineoplastic drugs, such as pharmacists, pharmacy technicians, and nurses. It was found statistically significant increases in the genotoxicity biomarkers in exposed comparising with controls (p<0.05). The findings address the need for regular biomonitoring of personnel occupationally exposed to these drugs, confirming to an enhanced health risk assessment.por
dc.identifier.citationLadeira C, Viegas S, Pádua M, Carolino E, Gomes MC, Brito M. Genotoxic assessment in different exposure groups working with antineoplastic agents. In Arezes PM, Baptista JS, Barroso MP, Carneiro P, Cordeiro P, Costa N, et al, editors. Occupational safety and hygiene III. London: Taylor & Francis; 2015. p. 177-80.por
dc.identifier.doi10.1201/b18042-37
dc.identifier.urihttp://hdl.handle.net/10400.21/4889
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherTaylor & Francispor
dc.relation.publisherversionhttp://www.amazon.com/Occupational-Safety-Hygiene-Pedro-Arezes/dp/1138027650#reader_1138027650por
dc.subjectOccupational healthpor
dc.subjectGenotoxic assessmentpor
dc.subjectAntineoplastic drugspor
dc.subjectCytostatic drugspor
dc.titleGenotoxic assessment in different exposure groups working with antineoplastic agentspor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage180por
oaire.citation.startPage177por
person.familyNameLadeira
person.familyNameViegas
person.familyNameCarolino
person.familyNameBrito
person.givenNameCarina
person.givenNameSusana
person.givenNameElisabete
person.givenNameMiguel
person.identifier144237
person.identifier248817
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person.identifier.ciencia-idA919-7318-63DC
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person.identifier.orcid0000-0001-5588-0074
person.identifier.orcid0000-0003-1015-8760
person.identifier.orcid0000-0003-4165-7052
person.identifier.orcid0000-0001-6394-658X
person.identifier.ridJ-2572-2012
person.identifier.ridI-4053-2012
person.identifier.ridF-1012-2015
person.identifier.ridA-7970-2016
person.identifier.scopus-author-id36463788000
person.identifier.scopus-author-id35270591500
person.identifier.scopus-author-id25821697000
person.identifier.scopus-author-id35224551000
rcaap.rightsopenAccesspor
rcaap.typearticlepor
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relation.isAuthorOfPublication.latestForDiscovery13115332-43f7-4048-a8a5-2f2b855a8c92

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