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Absolute hyperglycemia versus stress hyperglycemia ratio for the prognosis of hospitalized patients with COVID-19 in the first months of the pandemic: a retrospective study

2023-02Journal article Open access
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dc.contributor.authorMatias, Alexandra A.
dc.contributor.authorManique, Inês
dc.contributor.authorSabino, Teresa
dc.contributor.authorRego, Teresa
dc.contributor.authorMihon, Claudia
dc.contributor.authorPanarra, António
dc.contributor.authorRizzo, Manfredi
dc.contributor.authorSilva-Nunes, José
dc.date.accessioned2023-01-02T15:37:59Z
dc.date.available2023-01-02T15:37:59Z
dc.date.issued2023-02
dc.description.abstractDiabetes is a risk factor for the greater severity of coronavirus disease 2019 (COVID-19). The stress hyperglycemia ratio (SHR) is an independent predictor of critical illness, and it is reported to have a stronger association than absolute hyperglycemia. The aim of this study was to assess the relationship between absolute hyperglycemia and SHR with the severity of COVID-19 since there are no studies investigating SHR in patients with COVID-19. We conducted a retrospective observational study on hospitalized patients with COVID-19 in the first months of the pandemic, regarding absolute hyperglycemia, SHR, and severity outcomes. Of the 374 patients, 28.1% had a previous diagnosis of type 2 diabetes. Absolute hyperglycemia (64.8% versus 22.7%; p < 0.01) and SHR [1.1 (IQR 0.9-1.3) versus 1.0 (IQR 0.9-1.2); p < 0.001] showed a statistically significant association with previous diabetes. Absolute hyperglycemia showed a significant association with the clinical severity of COVID-19 (79.0% versus 62.7%; p < 0.001), need for oxygen therapy (74.8% versus 54.4%; p < 0.001), invasive mechanical ventilation (28.6% versus 11.6%; p < 0.001), and intensive care unit (30.3% versus 14.9%; p = 0.002), but not with mortality; by contrast, there was no statistically significant association between SHR and all these parameters. Our results are in agreement with the literature regarding the impact of absolute hyperglycemia on COVID-19 severity outcomes, while SHR was not a significant marker. We, therefore, suggest that SHR should not be evaluated in all patients admitted to the hospital for COVID-19, and we encourage the standard measures at the admission of blood glucose and HbA1c levels.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMatias AA, Manique I, Sabino T, Rego T, Mihon C, Silva-Nunes J, et al. Absolute hyperglycemia versus stress hyperglycemia ratio for the prognosis of hospitalized patients with COVID-19 in the first months of the pandemic: a retrospective study. Diabetes Ther. 2023;14(2):335-46.pt_PT
dc.identifier.doi10.1007/s13300-022-01347-4pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15220
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.relation.publisherversionhttps://link.springer.com/article/10.1007/s13300-022-01347-4pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCOVID-19pt_PT
dc.subjectDiabetespt_PT
dc.subjectHyperglycemiapt_PT
dc.subjectPrognosispt_PT
dc.subjectStress hyperglycemia ratiopt_PT
dc.titleAbsolute hyperglycemia versus stress hyperglycemia ratio for the prognosis of hospitalized patients with COVID-19 in the first months of the pandemic: a retrospective studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage346pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage335pt_PT
oaire.citation.titleDiabetes Therapypt_PT
oaire.citation.volume14pt_PT
person.familyNameSilva-Nunes
person.givenNameJosé António
person.identifier.ciencia-id4B1C-E132-25F0
person.identifier.orcid0000-0002-4728-1220
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication9352b380-9661-4316-ab88-6ed9be1020ac
relation.isAuthorOfPublication.latestForDiscovery9352b380-9661-4316-ab88-6ed9be1020ac

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