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Editorial: The cytoskeleton and cellular compartmentation: Cilia as specialized cellular domains

2021-10Journal article Open access
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dc.contributor.authorGarcia-Gonzalo, Francesc R.
dc.contributor.authorSoares, Helena
dc.contributor.authorLopes, Susana S.
dc.contributor.authorInoue, Takanari
dc.date.accessioned2021-11-15T11:06:52Z
dc.date.available2021-11-15T11:06:52Z
dc.date.issued2021-10
dc.descriptionFCT_UIDB/00100/2020. FCT_UIDP/00100/2020.pt_PT
dc.description.abstractCilia are fascinating microtubule-based compartments that project from the cell surface. Cilia can be functionally classified as motile (generating cell movement or fluid flow) or immotile (primary cilia, which transduce mechanical, optical, or chemical signals through a variety of pathways, such as Hedgehog, GPCR, Notch, Wnt, Hippo, mTOR, PDGFR, or TGFβ. Structurally, cilia are composed of a microtubule shaft (axoneme) that elongates from a membrane-anchored centriole (basal body) and are covered by a highly specialized ciliary membrane. Most human cell types form cilia, dysfunction of which leads to diseases such as cancer and ciliopathies, a diverse group of disorders affecting eyes, kidneys, and brain, among other organs. This Research Topic spans multiple aspects of motile and primary cilia composition and function, ciliary mechanisms, and the physiopathological roles of cilia in different tissues. Here we describe some of the highlights.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationGarcía-Gonzalo FR, Soares H, Lopes SS, Inoue T. Editorial: The cytoskeleton and cellular compartmentation: Cilia as specialized cellular domains. Front Cell Dev Biol. 2021;9:777758.pt_PT
dc.identifier.doi10.3389/fcell.2021.777758pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/13997
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationFCT_UIDB/00100/2020pt_PT
dc.relationFCT_UIDP/00100/2020pt_PT
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fcell.2021.777758/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPrimary ciliapt_PT
dc.subjectCiliopathiespt_PT
dc.subjectCiliogenesispt_PT
dc.subjectMotile/immotile ciliapt_PT
dc.subjectCilia signalingpt_PT
dc.subjectFCT_UIDB/00100/2020pt_PT
dc.subjectFCT_UIDP/00100/2020pt_PT
dc.titleEditorial: The cytoskeleton and cellular compartmentation: Cilia as specialized cellular domainspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage777758pt_PT
oaire.citation.titleFrontiers in Cell and Developmental Biologypt_PT
oaire.citation.volume9pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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