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Orientador(es)
Resumo(s)
Cilia are fascinating microtubule-based compartments that project from the cell surface. Cilia can be functionally classified as motile (generating cell movement or fluid flow) or immotile (primary cilia, which transduce mechanical, optical, or chemical signals through a variety of pathways, such as Hedgehog, GPCR, Notch, Wnt, Hippo, mTOR, PDGFR, or TGFβ. Structurally, cilia are composed of a microtubule shaft (axoneme) that elongates from a membrane-anchored centriole (basal body) and are covered by a highly specialized ciliary membrane. Most human cell types form cilia, dysfunction of which leads to diseases such as cancer and ciliopathies, a diverse group of disorders affecting eyes, kidneys, and brain, among other organs. This Research Topic spans multiple aspects of motile and primary cilia composition and function, ciliary mechanisms, and the physiopathological roles of cilia in different tissues. Here we describe some of the highlights.
Descrição
FCT_UIDB/00100/2020. FCT_UIDP/00100/2020.
Palavras-chave
Primary cilia Ciliopathies Ciliogenesis Motile/immotile cilia Cilia signaling FCT_UIDB/00100/2020 FCT_UIDP/00100/2020
Contexto Educativo
Citação
García-Gonzalo FR, Soares H, Lopes SS, Inoue T. Editorial: The cytoskeleton and cellular compartmentation: Cilia as specialized cellular domains. Front Cell Dev Biol. 2021;9:777758.
Editora
Frontiers Media