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The influence of number of counts in the myocardium in the determination of reproducible functional parameters in gated-SPECT studies simulated with GATE

2015-07Journal article Restricted access
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dc.contributor.authorVieira, Lina
dc.contributor.authorCosta, Durval C.
dc.contributor.authorAlmeida, Pedro
dc.date.accessioned2015-08-17T11:22:03Z
dc.date.available2015-08-17T11:22:03Z
dc.date.issued2015-07
dc.description.abstractMyocardial perfusion gated-single photon emission computed tomography (gated-SPECT) imaging is used for the combined evaluation of myocardial perfusion and left ventricular (LV) function. The aim of this study is to analyze the influence of counts/pixel and concomitantly the total counts in the myocardium for the calculation of myocardial functional parameters. Material and methods: Gated-SPECT studies were performed using a Monte Carlo GATE simulation package and the NCAT phantom. The simulations of these studies use the radiopharmaceutical 99mTc-labeled tracers (250, 350, 450 and 680MBq) for standard patient types, effectively corresponding to the following activities of myocardium: 3, 4.2, 5.4-8.2MBq. All studies were simulated using 15 and 30s/projection. The simulated data were reconstructed and processed by quantitative-gated-SPECT software, and the analysis of functional parameters in gated-SPECT images was done by using Bland-Altman test and Mann-Whitney-Wilcoxon test. Results: In studies simulated using different times (15 and 30s/projection), it was noted that for the activities for full body: 250 and 350MBq, there were statistically significant differences in parameters Motility and Thickness. For the left ventricular ejection fraction (LVEF), end-systolic volume (ESV) it was only for 250MBq, and 350MBq in the end-diastolic volume (EDV), while the simulated studies with 450 and 680MBq showed no statistically significant differences for global functional parameters: LVEF, EDV and ESV. Conclusion: The number of counts/pixel and, concomitantly, the total counts per simulation do not significantly interfere with the determination of gated-SPECT functional parameters, when using the administered average activity of 450MBq, corresponding to the 5.4MBq of the myocardium, for standard patient types.por
dc.identifier.citationVieira L, Costa DC, Almeida P. The influence of number of counts in the myocardium in the determination of reproducible functional parameters in gated-SPECT studies simulated with GATE. Rev Esp Med Nucl Imagen Mol. 2015;34(6):339-44.por
dc.identifier.doi10.1016/j.remn.2015.04.005
dc.identifier.urihttp://hdl.handle.net/10400.21/4763
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S2253654X15000578por
dc.subjectNuclear medicinepor
dc.subjectFunctional parameterspor
dc.subjectGATEpor
dc.subjectGated-SPECTpor
dc.subjectNCATpor
dc.subjectNumber of countspor
dc.subjectMyocardiumpor
dc.titleThe influence of number of counts in the myocardium in the determination of reproducible functional parameters in gated-SPECT studies simulated with GATEpor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleRevista Española de Medicina Nuclear e Imagen Molecularpor
rcaap.rightsrestrictedAccesspor
rcaap.typearticlepor

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