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Association between lung function and dyspnoea and its variation in the multinational Burden of Obstructive Lung Disease (BOLD) study

2025-01Journal article Open access
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dc.contributor.authorMüller, A.
dc.contributor.authorWouters, E. F.
dc.contributor.authorKoul, P.
dc.contributor.authorWelte, T.
dc.contributor.authorHarrabi, I.
dc.contributor.authorRashid, A.
dc.contributor.authorLoh, L. C.
dc.contributor.authorAl Ghobain, M.
dc.contributor.authorElsony, A.
dc.contributor.authorAhmed, R.
dc.contributor.authorPotts, J.
dc.contributor.authorMortimer, K.
dc.contributor.authorRodrigues, F.
dc.contributor.authorParaguas, S. N.
dc.contributor.authorJuvekar, S.
dc.contributor.authorAgarwal, D.
dc.contributor.authorObaseki, D.
dc.contributor.authorGislason, T.
dc.contributor.authorSeemungal, T.
dc.contributor.authorNafees, A. A.
dc.contributor.authorJenkins, C.
dc.contributor.authorDias, Hermínia Brites
dc.contributor.authorFranssen, F. M.
dc.contributor.authorStudnicka, M.
dc.contributor.authorJanson, C.
dc.contributor.authorCherkaski, H. H.
dc.contributor.authorEl Biaze, M.
dc.contributor.authorMahesh, P. A.
dc.contributor.authorCardoso, João
dc.contributor.authorBurney, P.
dc.contributor.authorHartl, S.
dc.contributor.authorJanssen, D. J.
dc.contributor.authorAmaral, A. F.
dc.date.accessioned2024-04-26T10:37:08Z
dc.date.available2024-04-26T10:37:08Z
dc.date.issued2025-01
dc.description.abstractBackground: Dyspnoea is a common symptom of respiratory disease. However, data on its prevalence in general populations and its association with lung function are limited and are mainly from high-income countries. This study aimed to estimate the prevalence of dyspnoea across several world regions and to investigate the association of dyspnoea with lung function. Methods: Dyspnoea was assessed, and lung function was measured in 25,806 adult participants of the multinational Burden of Obstructive Lung Disease study. Dyspnoea was defined as ≥2 on the modified Medical Research Council (mMRC) dyspnoea scale. The prevalence of dyspnoea was estimated for each of the study sites and compared across countries and world regions. Multivariable logistic regression was used to assess the association of dyspnoea with lung function in each site. Results were then pooled using random-effects meta-analysis. Results: The prevalence of dyspnoea varied widely across sites without a clear geographical pattern. The mean prevalence of dyspnoea was 13.7 % (SD=8.2 %), ranging from 0 % in Mysore (India) to 28.8 % in Nampicuan-Talugtug (Philippines). Dyspnoea was strongly associated with both spirometry restriction (FVC<LLN: OR 2.07, 95 %CI 1.75–2.45) and spirometry airflow obstruction (FEV1/FVC<LLN: OR 3.76, 95 %CI 1.04–4.65). These associations did not significantly differ between sexes, age groups, or smoking history. The association of dyspnoea with airflow obstruction was weaker among obese participants (OR 2.20, 95 %CI 1.61–3.01). Conclusion: The prevalence of dyspnoea varies substantially across the world and is strongly associated with lung function impairment. Using the mMRC scale in epidemiological research should be discussed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMüller A, Wouters EF, Koul P, Welte T, Harrabi I, Dias HB, et al. Association between lung function and dyspnoea and its variation in the multinational Burden of Obstructive Lung Disease (BOLD) study. Pulmonology. 2024 April 13, [In press, corrected proof].pt_PT
dc.identifier.doi10.1016/j.pulmoe.2024.03.005pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17391
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationWellcome Trust grant (085790/Z/08/Z)pt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S2531043724000448pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectPneumologypt_PT
dc.subjectDyspneapt_PT
dc.subjectBreathlessnesspt_PT
dc.subjectSpirometrypt_PT
dc.subjectLung functionpt_PT
dc.titleAssociation between lung function and dyspnoea and its variation in the multinational Burden of Obstructive Lung Disease (BOLD) studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titlePulmonologypt_PT
person.familyNameDias
person.givenNameMaria Hermínia Monteiro Brites
person.identifier.ciencia-idE211-FB1B-04E3
person.identifier.orcid0000-0003-1257-8734
person.identifier.ridAFL-8310-2022
person.identifier.scopus-author-id55671930200
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb7b7e7d9-83b2-4d63-9176-4ed73cf6b939
relation.isAuthorOfPublication.latestForDiscoveryb7b7e7d9-83b2-4d63-9176-4ed73cf6b939

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