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Refractory status epilepticus outcome: a retrospective study from a Portuguese hospital

2025-09Póster em conferência Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorPalhete-Ferreira, Lígia
dc.contributor.authorDias, J.
dc.contributor.authorPeralta, A. R.
dc.contributor.authorBentes, C.
dc.date.accessioned2026-04-20T15:14:51Z
dc.date.available2026-04-20T15:14:51Z
dc.date.issued2025-09
dc.descriptionH&TRC authors gratefully acknowledge FCT/MCTES national support through UIDB/05608/2020 and UIDP/05608/2020.
dc.description.abstractPurpose: Refractory Status Epilepticus (RSE) is a severe neurological emergency characterized by refractoriness to initial anti-seizure medications (ASM) and often requiring intravenous anesthetics therapy (IVAT) in an intensive care unit (ICU) setting. Despite previous efforts, biomarkers of successful RSE reversal are still lacking. Aim: study clinical predictors of successful IVAT weaning off and outcome in patients with RSE under IVAT. Method: Retrospective study including RSE adult patients, under optimized IVAT for at least 72h, between November 2017 and December 2018. Clinical and functional outcome (mRS) data were collected at ICU discharge and at the last follow-up time. The association between clinical variables, successful IVAT weaning-off, and functional outcome was analyzed using statistical methods. Results: 32 patients (mean age 67.6 years; mean time follow-up 17months) were included, and 58 IVAT weaning-off attempts were analyzed, of which 41,3% were successful. All patients with a previous epilepsy diagnosis had a successful IVAT weaning-off attempt (p=0,022). However, no clinical factor was found to be an independent predictor of successful IVAT weaning-off in our binary-logistic regression model. At ICU discharge, 96,6% patients had mRS >2, 36,2% had died, and there was a positive association between mRS score and age (p=0,000), RSE type (p=0,004; mostly focal-motor RSE) and etiology (p=0,006), number of ASMs (p=0,004), treatment with LCS (p=0,000) and VPA (p=0,004) and STESS score (p=0,000). At last follow-up, 90,9% patients had mRS >2, 86,4% had died, and there was an association between mRS score and RSE etiology (p=0,049; mostly acute-symptomatic) and CNS infection (p=0,022). Conclusion: This study shows a negative outcome associated with RSE. Successful IVAT weaning-off was more frequent in epilepsy patients. RSE patients’ functional outcome was associated with multiple clinical factors, although identification of independent predictors was not possible. Larger, prospective, and multimodal studies are needed to better understand refractory forms of RSE and outcome predictors.eng
dc.identifier.citationPalhete-Ferreira L, Dias J, Peralta AR, Bentes C. Refractory status epilepticus outcome: a retrospective study from a Portuguese hospital. In: 36th International Epilepsy Congress, Lisbon (Portugal), August 30 – September 3, 2025. Epilepsia. 2025;66 Suppl 4:S497. poster 1742.
dc.identifier.urihttp://hdl.handle.net/10400.21/22816
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWiley
dc.relation.hasversionhttps://onlinelibrary.wiley.com/toc/15281167/2025/66/S4
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectEpilepsia
dc.subjectRefractory status epilepticus
dc.subjectHospital
dc.subjectPortugal
dc.subjectFCT_UIDB/05608/2020
dc.subjectFCT_UIDP/05608/2020
dc.titleRefractory status epilepticus outcome: a retrospective study from a Portuguese hospitaleng
dc.typeconference poster
dspace.entity.typePublication
oaire.citation.conferenceDate2025-09
oaire.citation.conferencePlaceLisboa, Portugal
oaire.citation.issueSuppl 4
oaire.citation.startPageS497
oaire.citation.titleEpilepsia: Official journal of the International League Against Epilepsy
oaire.citation.volume66
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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