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Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 cells with gut tropism

2024-12Journal article Open access
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dc.contributor.authorZúquete, Sara
dc.contributor.authorFerreira, Mariana
dc.contributor.authorDelgado, Inês L. S.
dc.contributor.authorGazalle, Paula
dc.contributor.authorAndaluz, Stephanie
dc.contributor.authorRosa, Maria Teresa
dc.contributor.authorMendes, Ana Catarina
dc.contributor.authorSantos, Dulce
dc.contributor.authorNolasco, Sofia
dc.contributor.authorGraça, Luís
dc.contributor.authorLeitão, Alexandre
dc.contributor.authorBasto, Afonso P.
dc.date.accessioned2024-11-18T15:37:28Z
dc.date.available2024-11-18T15:37:28Z
dc.date.issued2024-12
dc.descriptionThis work was funded by Fundação para a Ciência e Tecnologia (FCT; Portugal) through the projects grants PTDC/CVT-CVT/31840/2017, PTDC/CVT-CVT/4599/2021, 2022.04903.PTDC, LA/P/0059/2020 (AL4AnimalS – Associate Laboratory for Animal and Veterinary Sciences), UID/CVT/00276/2019 and UIDB/00276/2020 (CIISA – Center for Interdisciplinary Research in Animal Health, Faculty of Veterinary Medicine, University of Lisbon). Funding was also provided by Fundación ’la Caixa’ through the project HR22-00741.pt_PT
dc.description.abstractActivated CD4+ T cells located at mucosal surfaces orchestrate local effector immune mechanisms. When properly polarized, these cells contribute to block infections at early stages and may be essential to restrain the local growth of mucosal tumors, playing a critical role in host protection. How CD4+ T cells simultaneously integrate gut-homing instructions and Th polarization signals transmitted by TLR-activated dendritic cells (DCs) is unknown. Here, we show that the combined activation through TLR2, which alone does not induce a clear Th polarization, and TLR4, which alone does not imprint mucosal tropism, equip non-mucosal DCs to prime gut-homing CD4+ T cells with reinforced Th1 polarization. These results show that targeting DCs with combined innate stimuli with distinct properties is a rational strategy to program the outcome of T cell polarization and simultaneously control their tissue tropism. Exploring this strategy could enhance the efficacy of vaccines and immune cell therapies.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZúquete S, Ferreira M, Delgado IL, Gazalle P, Andaluz S, Nolasco S, et al. Combined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 cells with gut tropism. iScience. 2024;27(12):111232.pt_PT
dc.identifier.doi10.1016/j.isci.2024.111232pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17927
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S258900422402457Xpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectNatural sciencespt_PT
dc.subjectBiological sciencespt_PT
dc.subjectImmunologypt_PT
dc.subjectImmune systempt_PT
dc.titleCombined TLR2/TLR4 activation equip non-mucosal dendritic cells to prime Th1 cells with gut tropismpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12pt_PT
oaire.citation.startPage111232pt_PT
oaire.citation.titleiSciencept_PT
oaire.citation.volume27pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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