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Cellular uptake of BCG-loaded chitosan microparticles and in vivo evaluation of immune response following intranasal immunisation

2013-04Conference object Open access
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dc.contributor.authorCaetano, Liliana Aranha
dc.contributor.authorFigueiredo, Lara
dc.contributor.authorAmaral, Rita
dc.contributor.authorAlmeida, António José
dc.contributor.authorGonçalves, Lídia Maria Diogo
dc.date.accessioned2013-09-24T14:35:49Z
dc.date.available2013-09-24T14:35:49Z
dc.date.issued2013-04
dc.description.abstractAttenuated Mycobacterium bovis bacillus Calmette-Guérin (BCG) is the only currently available vaccine against tuberculosis. It is highly effective in pre-exposure immunisation against TB in children when administered by subcutaneous route to newborns. However, it does not provide permanent protection in adults. In this work, polymeric chitosan-alginate microparticles have been evaluated as potential nasal delivery systems and mucosal adjuvants for live attenuated BCG. Chitosan (CS) has been employed as adjuvant and mucosal permeation-enhancer, and, together with alginate (ALG), as additive to enhance BCG-loaded microparticles (MPs) cellular uptake in a human monocyte cell line, by particle surface modification. The most suitable particles were used for vaccine formulation and evaluation of immune response following intranasal immunisation of BALB/c mice.por
dc.identifier.citationCaetano LA, Figueiredo L, Amaral R, Almeida AJ, Gonçalves LM. Cellular uptake of BCG-loaded chitosan microparticles and in vivo evaluation of immune response following intranasal immunization. In EUCHIS 2013 Congress, Porto, 5th to 8th May 2013.por
dc.identifier.urihttp://hdl.handle.net/10400.21/2701
dc.language.isoengpor
dc.peerreviewedyespor
dc.relation.publisherversionhttp://www.skyros-congressos.pt/euchis2013/por
dc.subjectBCGpor
dc.subjectBacillus Calmette-Guérinpor
dc.subjectTuberculosispor
dc.subjectPolymeric chitosan-alginate microparticlespor
dc.subjectChitosanpor
dc.subjectMucosal immunisationpor
dc.titleCellular uptake of BCG-loaded chitosan microparticles and in vivo evaluation of immune response following intranasal immunisationpor
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopor
rcaap.rightsopenAccesspor
rcaap.typeconferenceObjectpor

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