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Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease

2021-02Journal article Open access
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dc.contributor.authorMateus, Vanessa
dc.contributor.authorEstarreja, João
dc.contributor.authorSilva, Inês
dc.contributor.authorBarracosa, Paulo
dc.contributor.authorTeixeira-Lemos, Edite
dc.contributor.authorPinto, Rui
dc.date.accessioned2021-02-12T20:24:19Z
dc.date.available2021-02-12T20:24:19Z
dc.date.issued2021-02
dc.descriptionUIDB/05608/2020 and UIDP/05608/2020pt_PT
dc.description.abstractBackground: Cynara cardunculus L. var. altilis (DC) is a plant generally associated as an ingredient in the Mediterranean diet. The polyphenols present in this plant provide pharmacological and nutritional properties. C. cardunculus L. has been used throughout animal studies, which demonstrated an anti-inflammatory effect. Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract. Since there is not a known cure, the research of new possible pharmacological approaches is essential. This study aims to evaluate the effect of an aqueous extract of C. cardunculus L. dry leaves in a 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis model. Methods: CD-1 mice with TNBS-induced colitis received an intraperitoneal (IP) administration of C. cardunculus L. once per day for 4 days. Results: The C. cardunculus L. demonstrated a beneficial effect in this experimental model of IBD with anti-inflammatory action through the reduction of tumor necrosis factor (TNF)-α levels. It also demonstrated a beneficial influence on the extra-intestinal manifestations related to IBD, with the absence of significant side effects of its use. Conclusions: The extract of C. cardunculus L. dry leaves can become an interesting tool for new possible pharmacological approaches in the management of IBD.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMateus V, Estarreja J, Silva I, Barracosa P, Teixeira-Lemos E, Pinto R. Effect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel disease. Appl Sci. 2021;11(4):1629.pt_PT
dc.identifier.doi10.3390/app11041629pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/12842
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationFCT_UIDB/05608/2020pt_PT
dc.relationFCT_UIDP/05608/2020pt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2076-3417/11/4/1629pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectCardoonpt_PT
dc.subjectCynara cardunculus L.pt_PT
dc.subjectPolyphenolspt_PT
dc.subjectColitispt_PT
dc.subjectInflammationpt_PT
dc.subjectInflammatory bowel diseasept_PT
dc.subjectTNBS-induced colitispt_PT
dc.subjectHerbal medicinespt_PT
dc.subjectUIDB/05608/2020pt_PT
dc.subjectUIDP/05608/2020pt_PT
dc.titleEffect of Cynara cardunculus L. var. altilis (DC) in inflammatory bowel diseasept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPage1629pt_PT
oaire.citation.titleApplied Sciencespt_PT
oaire.citation.volume11pt_PT
person.familyNamePinho Mateus
person.familyNameEstarreja
person.familyNameda Silva
person.givenNameVanessa Alexandra
person.givenNameJoão
person.givenNameInês Filipa Janeiro da Silva
person.identifier.ciencia-id5A12-571D-AD6A
person.identifier.ciencia-idEB19-EDA2-704B
person.identifier.ciencia-idC010-323F-3266
person.identifier.orcid0000-0002-3204-3772
person.identifier.orcid0000-0002-8283-3174
person.identifier.orcid0000-0001-7049-2512
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication406041a5-682c-4f94-a4e2-ddbfc541313c
relation.isAuthorOfPublicationd16a20d0-ac73-4989-b83d-abeab53139f7
relation.isAuthorOfPublication995e1831-ff5b-49e7-a6e3-8bc692212204
relation.isAuthorOfPublication.latestForDiscovery406041a5-682c-4f94-a4e2-ddbfc541313c

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