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Carcinogenicity of tris(chloropropyl) phosphate, butyraldehyde, and cumyl hydroperoxide

2026-03Artigo científico Acesso aberto
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datacite.subject.sdg03:Saúde de Qualidade
dc.contributor.authorLachenmeier, Dirk W.
dc.contributor.authorArrandale, Victoria H.
dc.contributor.authorDeMarini, David M.
dc.contributor.authorRuksha, Tatiana
dc.contributor.authorAbdallah, Mohamed A-E
dc.contributor.authorBettini, Giuliano
dc.contributor.authorIshii, Yuji
dc.contributor.authorLadeira, Carina
dc.contributor.authorPi, Jingbo
dc.contributor.authorRossner, Pavel
dc.contributor.authorRyan, Kristen R.
dc.contributor.authorStefanska, Barbara
dc.contributor.authorVan Gerwen, Maaike
dc.contributor.authorVenier, Marta
dc.contributor.authorConti, Aline de
dc.contributor.authorFacchin, Caterina
dc.contributor.authorKunzmann, Andrew T.
dc.contributor.authorMadia, Federica
dc.contributor.authorPasqual, Elisa
dc.contributor.authorWedekind, Roland
dc.contributor.authorAl Nahas, Aline
dc.contributor.authorCoutaz-Repland, Seyederoya
dc.contributor.authorOhene-Agyei, Phyllis
dc.contributor.authorSuonio, Eero
dc.contributor.authorMattock, Heidi
dc.contributor.authorBenbrahim-Tallaa, Lamia
dc.contributor.authorSchubauer-Berigan, Mary K.
dc.date.accessioned2026-04-17T08:05:39Z
dc.date.available2026-04-17T08:05:39Z
dc.date.issued2026-03
dc.description.abstractIn March 2026, a Working Group of 12 scientists from nine countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to finalise their evaluation of the carcinogenicity of tris(chloropropyl) phosphate (TCPP), butyraldehyde, and cumyl hydroperoxide. TCPP was classified as “probably carcinogenic to humans” (Group 2A) based on the combination of “sufficient” evidence for cancer in experimental animals and “strong” mechanistic evidence in human primary cells. Butyraldehyde was classified as “possibly carcinogenic to humans” (Group 2B) based on “sufficient” evidence for cancer in experimental animals and on “strong” mechanistic evidence in experimental systems. Cumyl hydroperoxide was classified as “possibly carcinogenic to humans” (Group 2B) based on “strong” mechanistic evidence in human primary cells and experimental systems. These assessments will be published in Volume 141 of the IARC Monographs.eng
dc.identifier.citationLachenmeier DW, Arrandale VH, DeMarini DM, Ruksha T, Abdallah MA, Ladeira C, et al. Carcinogenicity of tris(chloropropyl) phosphate, butyraldehyde, and cumyl hydroperoxide. Lancet Oncol. 2026 Mar 27:S1470-2045(26)00168-3. Epub ahead of print.
dc.identifier.doi10.1016/s1470-2045(26)00168-3
dc.identifier.issn1470-2045
dc.identifier.urihttp://hdl.handle.net/10400.21/22798
dc.language.isoeng
dc.peerreviewedyes
dc.publisherElsevier BV
dc.relation.hasversionhttps://www.sciencedirect.com/science/article/pii/S1470204526001683
dc.relation.ispartofThe Lancet Oncology
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectCarcinogenicity
dc.subjectTris(chloropropyl) phosphate
dc.subjectButyraldehyde
dc.subjectCumyl hydroperoxide
dc.titleCarcinogenicity of tris(chloropropyl) phosphate, butyraldehyde, and cumyl hydroperoxideeng
dc.typejournal article
dspace.entity.typePublication
oaire.citation.titleThe Lancet Oncology
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85
person.familyNameLadeira
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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