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Poly(DL-lactic acid) scaffolds adsorbed with minocycline and voriconazole: a new pathway towards infection containment

2021-09Conference object Open access
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dc.contributor.authorZegre, Miguel
dc.contributor.authorHenriques, M.
dc.contributor.authorSantos, C.
dc.contributor.authorRibeiro, I. A.
dc.contributor.authorCaetano, Liliana Aranha
dc.contributor.authorGonçalves, Lídia M.
dc.contributor.authorBettencourt, Ana F.
dc.date.accessioned2022-03-14T13:22:58Z
dc.date.available2022-03-14T13:22:58Z
dc.date.issued2021-09
dc.description.abstractBone infection (osteomyelitis): burden as a clinical complication of orthopedic surgeries. Controlled antimicrobial release systems: treat and prevent osteomyelitis. Biomaterials based on porous scaffolds: local administration of high concentration of drugs; no systemic toxicity; extended time. Scaffolds in bone tissue engineering: a combination of bioresorbable polymers with bioactive bioglasses; present biodegradability and biosafety; suitable microenvironment and structure; favor osteogenic differentiation and cell growth. Co-encapsulation of drugs: advantageous means for administration of drugs; novel strategy directed to the co-delivery of two antimicrobials (voriconazole and minocycline).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationZegre M, Henriques M, Santos C, Ribeiro IA, Caetano LA, Gonçalves L, et al. Poly(DL-lactic acid) scaffolds adsorbed with minocycline and voriconazole: a new pathway towards infection containment. In: 31st Conference of the European Society for Biomaterials [online], University of Porto (Portugal), September 5-9, 2021.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/14450
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.relation.publisherversionhttps://esb2021.org/scientific-program/pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectScaffoldspt_PT
dc.subjectMinocyclinept_PT
dc.subjectVoriconazolept_PT
dc.subjectOsteomyelitispt_PT
dc.subjectLocal antimicrobial therapypt_PT
dc.titlePoly(DL-lactic acid) scaffolds adsorbed with minocycline and voriconazole: a new pathway towards infection containmentpt_PT
dc.typeconference object
dspace.entity.typePublication
oaire.citation.conferencePlacePortopt_PT
person.familyNameAranha Caetano
person.givenNameLiliana
person.identifier.ciencia-id9716-9DAC-532A
person.identifier.orcid0000-0003-1496-2609
rcaap.rightsopenAccesspt_PT
rcaap.typeconferenceObjectpt_PT
relation.isAuthorOfPublication6517c656-f913-4f54-8682-77c2856c9e4c
relation.isAuthorOfPublication.latestForDiscovery6517c656-f913-4f54-8682-77c2856c9e4c

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