Poly(DL-lactic acid) scaffolds adsorbed with minocycline and voriconazole: a new pathway towards infection containment

Zegre, Miguel; Henriques, M.; Santos, C.; Ribeiro, I. A.; Caetano, Liliana Aranha; Gonçalves, Lídia M.; Bettencourt, Ana F.

http://hdl.handle.net/10400.21/14450

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Authors

Caetano, Liliana Aranha

Gonçalves, Lídia M.

Bettencourt, Ana F.

Abstract(s)

Bone infection (osteomyelitis): burden as a clinical complication of orthopedic surgeries. Controlled antimicrobial release systems: treat and prevent osteomyelitis. Biomaterials based on porous scaffolds: local administration of high concentration of drugs; no systemic toxicity; extended time. Scaffolds in bone tissue engineering: a combination of bioresorbable polymers with bioactive bioglasses; present biodegradability and biosafety; suitable microenvironment and structure; favor osteogenic differentiation and cell growth. Co-encapsulation of drugs: advantageous means for administration of drugs; novel strategy directed to the co-delivery of two antimicrobials (voriconazole and minocycline).

Keywords

Scaffolds Minocycline Voriconazole Osteomyelitis Local antimicrobial therapy

URI

http://hdl.handle.net/10400.21/14450

Citation

Zegre M, Henriques M, Santos C, Ribeiro IA, Caetano LA, Gonçalves L, et al. Poly(DL-lactic acid) scaffolds adsorbed with minocycline and voriconazole: a new pathway towards infection containment. In: 31st Conference of the European Society for Biomaterials [online], University of Porto (Portugal), September 5-9, 2021.