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Advisor(s)
Abstract(s)
Bone infection (osteomyelitis): burden as a clinical complication of orthopedic surgeries. Controlled antimicrobial release systems: treat and prevent osteomyelitis. Biomaterials based on porous scaffolds: local administration of high concentration of drugs; no systemic toxicity; extended time. Scaffolds in bone tissue engineering: a combination of bioresorbable polymers with bioactive bioglasses; present biodegradability and biosafety; suitable microenvironment and structure; favor osteogenic differentiation and cell growth. Co-encapsulation of drugs: advantageous means for administration of drugs; novel strategy directed to the co-delivery of two antimicrobials (voriconazole and minocycline).
Description
Keywords
Scaffolds Minocycline Voriconazole Osteomyelitis Local antimicrobial therapy
Citation
Zegre M, Henriques M, Santos C, Ribeiro IA, Caetano LA, Gonçalves L, et al. Poly(DL-lactic acid) scaffolds adsorbed with minocycline and voriconazole: a new pathway towards infection containment. In: 31st Conference of the European Society for Biomaterials [online], University of Porto (Portugal), September 5-9, 2021.