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Comparison of multi-locus genotypes detected in Aspergillus fumigatus isolated from COVID associated pulmonary aspergillosis (CAPA) and from other clinical and environmental sources

2023-02Artigo científico Acesso aberto
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dc.contributor.authorMorais, Susana
dc.contributor.authorToscano, Cristina
dc.contributor.authorSimões, Helena
dc.contributor.authorCarpinteiro, Dina
dc.contributor.authorViegas, Carla
dc.contributor.authorVeríssimo, Cristina
dc.contributor.authorSabino, Raquel
dc.date.accessioned2023-02-28T12:14:41Z
dc.date.available2023-02-28T12:14:41Z
dc.date.issued2023-02
dc.description.abstractBackground: Aspergillus fumigatus is a saprophytic fungus, ubiquitous in the environment, and responsible for causing infections, some of them severe invasive infections. The high morbidity and mortality, together with the increasing burden of triazole-resistant isolates and the emergence of new risk groups, namely COVID-19 patients, have raised a crescent awareness of the need to better comprehend the dynamics of this fungus. The understanding of the epidemiology of this fungus, especially of CAPA isolates, allows a better understanding of the interactions of the fungus in the environment and the human body. Methods: In the present study, the M3 markers of the STRAf assay were used as a robust typing technique to understand the connection between CAPA isolates and isolates from different sources (environmental and clinical-human and animal). Results: Of 100 viable isolates that were analyzed, 85 genotypes were found, 77 of which were unique. Some isolates from different sources presented the same genotype. Microsatellite genotypes obtained from A. fumigatus isolates from COVID+ patients were all unique, not being found in any other isolates of the present study or even in other isolates deposited in a worldwide database; these same isolates were heterogeneously distributed among the other isolates. Conclusions: Isolates from CAPA patients revealed high heterogeneity of multi-locus genotypes. A genotype more commonly associated with COVID-19 infections does not appear to exist.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMorais S, Toscano C, Simões H, Carpinteiro D, Viegas C, Veríssimo C, et al. Comparison of multi-locus genotypes detected in Aspergillus fumigatus isolated from COVID associated pulmonary aspergillosis (CAPA) and from other clinical and environmental sources. J Fungi. 2023;9(3):298.pt_PT
dc.identifier.doi10.3390/jof9030298pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/15718
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relation.publisherversionhttps://www.mdpi.com/2309-608X/9/3/298pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectOccupational healthpt_PT
dc.subjectOccupational exposurept_PT
dc.subjectAspergillus fumigatuspt_PT
dc.subjectCAPApt_PT
dc.subjectSTRAf assaypt_PT
dc.subjectMicrosatellitept_PT
dc.subjectGenotypingpt_PT
dc.titleComparison of multi-locus genotypes detected in Aspergillus fumigatus isolated from COVID associated pulmonary aspergillosis (CAPA) and from other clinical and environmental sourcespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue3pt_PT
oaire.citation.startPage298pt_PT
oaire.citation.titleJournal of Fungipt_PT
oaire.citation.volume9pt_PT
person.familyNameViegas
person.givenNameCarla
person.identifier.ciencia-idEE1E-C639-D70F
person.identifier.orcid0000-0002-1545-6479
person.identifier.ridB-7217-2013
person.identifier.scopus-author-id55443609700
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublicationb5fa5da4-50c3-4b88-ae20-1bc63cb485f7
relation.isAuthorOfPublication.latestForDiscoveryb5fa5da4-50c3-4b88-ae20-1bc63cb485f7

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