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The use of effect biomarkers in chemical mixtures risk assessment: are they still important?

2024-05Journal article Embargoed access
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dc.contributor.authorLadeira, Carina
dc.date.accessioned2024-05-24T10:29:16Z
dc.date.embargo2026-05-24
dc.date.issued2024-05
dc.descriptionThe author thanks to H&TRC- Health & Technology Research Center - Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa; FCT/MCTES national support through the UIDP/05608/2020, UIDB/05608/2020, and IPL/2021/PLASCOGEN_ESTeSL.pt_PT
dc.description.abstractHuman epidemiological studies with biomarkers of effect play an invaluable role in identifying the health effects of chemical exposures and in disease prevention. Effect biomarkers that measure genetic damage are potent tools to address the carcinogenic and/or mutagenic potential of chemical exposures, increasing confidence in regulatory risk assessment decision-making processes. The micronucleus (MN) test is recognized as one of the most successful and reliable assays to assess genotoxic events, which are associated with exposures that may cause cancer. To move towards the next generation of risk assessment it is crucial to establish bridges between standard approaches, new approach methodologies (NAMs), and tools for increasing the mechanistically-based biological plausibility in human studies, such as the adverse outcome pathways (AOPs) framework. This paper aims to highlight the still active role of MN as a biomarker of effect in the evolution and applicability of new methods and approaches in human risk assessment, with the positive consequence, that the new methods provide a deeper knowledge of the mechanistically-based biology of these endpoints.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLadeira C. The use of effect biomarkers in chemical mixtures risk assessment: are they still important? Mutat Res Genet Toxicol Environ Mutagen. 2024;896:503768.pt_PT
dc.identifier.doi10.1016/j.mrgentox.2024.503768pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.21/17466
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationIPL/2021/PLASCOGEN_ESTeSLpt_PT
dc.relation.publisherversionhttps://www.sciencedirect.com/science/article/pii/S1383571824000445pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectGenotoxicitypt_PT
dc.subjectMicronucleuspt_PT
dc.subjectChemical mixturespt_PT
dc.subjectAdverse outcome pathwayspt_PT
dc.subjectNew approach methodologiespt_PT
dc.subjectHuman risk assessmentpt_PT
dc.subjectIPL/2021/PLASCOGEN_ESTeSLpt_PT
dc.subjectFCT_UIDP/05608/2020pt_PT
dc.subjectFCT_UIDB/05608/2020pt_PT
dc.titleThe use of effect biomarkers in chemical mixtures risk assessment: are they still important?pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage503768pt_PT
oaire.citation.titleMutation Research - Genetic Toxicology and Environmental Mutagenesispt_PT
oaire.citation.volume896pt_PT
person.familyNameLadeira
person.givenNameCarina
person.identifier144237
person.identifier.ciencia-id801C-1BBA-1D9E
person.identifier.orcid0000-0001-5588-0074
person.identifier.ridJ-2572-2012
person.identifier.scopus-author-id36463788000
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isAuthorOfPublication1aef4b60-4197-436b-84ab-80d31cbaed33
relation.isAuthorOfPublication.latestForDiscovery1aef4b60-4197-436b-84ab-80d31cbaed33

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