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Authors
Advisor(s)
Abstract(s)
Human epidemiological studies with biomarkers of effect play an invaluable role in identifying the health effects of chemical exposures and in disease prevention. Effect biomarkers that measure genetic damage are potent tools to address the carcinogenic and/or mutagenic potential of chemical exposures, increasing confidence in regulatory risk assessment decision-making processes. The micronucleus (MN) test is recognized as one of the most successful and reliable assays to assess genotoxic events, which are associated with exposures that may cause cancer. To move towards the next generation of risk assessment it is crucial to establish bridges between standard approaches, new approach methodologies (NAMs), and tools for increasing the mechanistically-based biological plausibility in human studies, such as the adverse outcome pathways (AOPs) framework. This paper aims to highlight the still active role of MN as a biomarker of effect in the evolution and applicability of new methods and approaches in human risk assessment, with the positive consequence, that the new methods provide a deeper knowledge of the mechanistically-based biology of these endpoints.
Description
The author thanks to H&TRC- Health & Technology Research Center - Escola Superior de Tecnologia da Saúde, Instituto Politécnico de Lisboa; FCT/MCTES national support through the UIDP/05608/2020, UIDB/05608/2020, and IPL/2021/PLASCOGEN_ESTeSL.
Keywords
Genotoxicity Micronucleus Chemical mixtures Adverse outcome pathways New approach methodologies Human risk assessment IPL/2021/PLASCOGEN_ESTeSL FCT_UIDP/05608/2020 FCT_UIDB/05608/2020
Citation
Ladeira C. The use of effect biomarkers in chemical mixtures risk assessment: are they still important? Mutat Res Genet Toxicol Environ Mutagen. 2024;896:503768.
Publisher
Elsevier